Radiochemistry Core

放化芯 放射化学核心的主要职能是执行良好的制造程序(GMP) 为支持试点项目进行研究所需的所有放射性示踪剂的合成。核心将是 马赫博士是宾夕法尼亚大学回旋加速器设施的主任，拥有超过30名 在PET放射化学领域有多年经验。李小菊博士，宾夕法尼亚回旋加速器设施经理， 将监督该设施的日常运营。她有十多年的GMP生产经验 在过去的5年里，他一直与马赫博士密切合作。对此修订后的补充内容 申请是耶鲁大学参与这个P30中心；放射化学组件的P.I. 耶鲁大学PET中心的黄益云(Henry)博士开发了这个P30中心使用的卡帕放射性示踪剂。 除了生产PET放射性示踪剂的GMP外，放化核心还将负责 合成试验项目中描述的研究所需的所有前体和高效液相标准 这是商业来源无法获得的。作为P30中心资源共享计划的一部分，这些 专有前体和标准将作为一种手段与宾夕法尼亚大学以外的NIDA资助的调查人员共享 加快对阿片类药物使用障碍和神经炎症的神经生物学的PET成像研究。一个 放射化学核心的最终功能是进行动脉血液样本的代谢物分析 数据分析小组进行输入功能测量所需的PET成像研究(由 耶鲁大学PET中心理查德·卡森博士)。

RADIOCHEMISTRY CORE The main function of the Radiochemistry Core is to conduct the Good Manufacturing Procedures (GMP) synthesis of all radiotracers needed to conduct the research in support of the pilot projects. The core will be directed by Robert H. Mach, Ph.D. Dr. Mach is the Director of the Penn Cyclotron Facility and has over thirty years of experience in the field of PET radiochemistry. Hsiaoju Lee, Ph.D., the Penn Cyclotron Facility Manager, will oversee the day-to-day operation of the facility. She has over ten years of experience in the GMP production of PET radiotracers and has worked closely with Dr. Mach for the past 5 years. An addition to this revised application is the involvement of Yale University in this P30 Center; the P.I. of the radiochemistry component for the Yale PET Center is Dr. Yiyun (Henry) Huang, who developed the kappa radiotracer used in this P30 Center. In addition to the GMP production of PET radiotracers, the Radiochemistry Core will be responsible for the synthesis of all precursors and HPLC standards that are required for the research described in the pilot projects that are not available from commercial sources. As part of the Resource Sharing Plan for this P30 Center, these proprietary precursors and standards will be shared with NIDA-funded investigators outside of Penn as a means of accelerating PET imaging research on the neurobiology of opiate use disorders and neuroinflammation. A final function of the Radiochemistry Core is to conduct the metabolite analysis of arterial blood samples from the PET imaging studies that is required for input function measurements by the data analysis group (directed by Dr. Richard Carson, Yale University PET Center).