CORE D: Magnetic Resonance Imaging Core (MRIC)

CORE D：磁共振成像核心（MRIC） 抽象的。 磁共振成像核心将位于UTHSCSA研究成像研究所（RII）， 离得克萨斯生物医学研究所大约5百万英里。RII的使命是提供 协作访问生物医学研究社区先进的，非侵入性的，成像研究 方法.这一使命是通过维持一个最先进的设施来实现的， 公认的专门从事成像方法开发的研究人员团队。磁共振 磁共振成像（MRI）和磁共振波谱（MRS）具有突出的跨物种翻译- 研究潜力，被应用于非人类灵长类动物（NHP）一样容易对人类。的研究人员 RII已经使用MRI/MRS对狒狒的大脑、心脏和肝脏进行了研究， 本节的参考书目。由彼得博士领导的衰老-发展规划研究小组 在Nathanielsz的领导下， 在狒狒模型中研究发育规划的技术。Nathanielsz博士的团队 在过去的十年里，我与RII的研究人员合作，这种合作为这一核心提供了信息和动力。 提议RII/MRIC成像仪器和专业知识强调MRI和MRS，因为它们共同 提供了大量的解剖/结构，功能/生理和生化指标， 非人类灵长类动物（NHP）研究专用仪器。RII/MIC仪器包括临床- 用于灵长类动物研究的3级特斯拉MRI/MRS系统。该系统配备了32个射频通道 使其能够利用并行成像进行功能性心脏和神经MRI研究 技术. MRI Core中生成的RI研究将用于测量尺寸、功能、总流量 组织灌注、组织微结构和体内生物化学。这些研究将在大脑中进行， 心脏、胸腺、骨骼肌和肝脏/腹部。动物成像仪器与直接 最先进的兽医护理设施所有狒狒MRI研究将由经认证的 兽医在整个过程中监测受试者。为了支持这一协调良好的努力， MRI Core将提供翻译成像资源， 专业知识此外，二十多年来，RII一直是区域和国家共享资源， 与许多其他机构的研究人员开展合作。在这一建议中， 特别是与心脏病、糖尿病、肥胖症的发展程序的后果有关， 和代谢综合征，以及它们对狒狒模型中正常衰老的生命过程的影响。的MRI Core支持U19应用程序的项目1、2和3。MRI核心的效用已经确立 通过之前的合作，包括西南国家灵长类动物研究中心和 Barshop长寿和衰老研究所。 !

CORE D: Magnetic Resonance Imaging Core (MRIC) Abstract. The Magnetic Resonance Imaging Core will be located at the UTHSCSA Research Imaging Institute (RII), which is about 5 m miles away from Texas Biomedical Research Institute. The mission of the RII is to provide collaborative access to the biomedical research community advanced, noninvasive, imaging-research methods. This mission is achieved by maintaining a state-of-the-art facility staffed by an internationally recognized team of investigators specializing in the development of imaging methods. Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have outstanding trans-species translational- research potential, being applied to non-human primates (NHP) as readily as to humans. The researchers at the RII have used MRI/MRS for studies of baboon brains, hearts and liver, with 26 such studies listed in the bibliography of this section. The aging-developmental programming research group, under Dr. Peter Nathanielsz' leadership, has been at the forefront of introducing non-invasive, advanced biomedical imaging techniques to the study of developmental programming in the baboon model. Dr. Nathanielsz' team has collaborated with RII investigators for the past decade, a collaboration that informs and motivates this core proposal. RII/MRIC imaging instrumentation & expertise emphasizes MRI and MRS because these jointly provide a huge range of anatomical/structural, functional/physiological and biochemical measures with instrumentation dedicated to non-human primate (NHP) research. RII/MIC instrumentation includes a clinical- grade 3 Tesla MRI/MRS system for primate studies. This system is equipped with 32 radiofrequency channels allowing it to perform functional cardiac and neuro MRI studies by taking advantage of parallel imaging technology. RI studies generated in the MRI Core will be used to measure changes in size, function, bulk flow, tissue perfusion, tissue microstructure and in vivo biochemistry. These studies will be carried out in brain, heart, thymus, skeletal muscle and liver/abdomen. Animal-imaging instrumentation is housed with direct access to a state-of-the art veterinary care facility. All baboon MRI studies will be conducted with a certified veterinarian monitoring the subjects through the procedures. In support of this well-coordinated effort by a highly sophisticated team of investigators, the MRI Core will provide translation imaging resources and expertise. Further, for more than two decades the RII has served as a regional and national shared resource, hosting collaborations with investigators from many other institutions. In this proposal, this role is expanded specifically in relation to the consequences of developmental programming of heart disease, diabetes, obesity and metabolic syndrome, and their effects on the life-course of normal aging in the baboon model. The MRI Core supports Projects 1, 2, and 3 of this U19 application. The utility of the MRI Core has been established through previous collaborations jointly involving the Southwest National Primate Research Center and the Barshop Institute for Longevity and Aging Studies. !