Pilot/Exploratory Studies Core

初步/探索性研究核心（PESC）：项目总结 试点/探索性研究核心（PESC）的总体目标是培养和支持尖端试点 和探索性研究，将促进有效预防和/或治疗虚弱的发展 从而促进老年人的独立性。PESC核心领导人与其他领导人密切合作， 核心领导人，为脆弱性研究的下一阶段设定科学目标，然后努力确定 调查人员的专业知识和职业目标将适用于促进我们在 目标地区。这些领导人寻找试点和探索性研究，可以收集所需的数据， 选择或设计未来建立脆弱机制所需的大规模或验证性研究， 确定病因，或开发新的治疗和筛查方法。选定供资的研究 这个周期的第一年包括一项研究，引导一种行为干预，同时解决疼痛 一项代谢组学研究，旨在确定与脆弱有关的 通过C13标记的葡萄糖耐量试验检测能量失调的代谢物特征， 旨在通过识别睡眠障碍和虚弱之间的联系， 具体的多导睡眠图签名牵连，使用功能数据分析，并探索潜在的 循环关系。PESC的具体目标是：1）推进脆弱的科学和翻译 通过提供必要的智力领导来确定目标研究领域， 能够最好地实现本OAIC的转化目标的调查人员，2）支持开发 精心设计和信息丰富的试点研究，3）提供和进行纵向辅导，以支持 研究人员通过完成试点奖励和寻求下一阶段研究的资金，4） 进一步指导任何试点研究结果的翻译，5）扩大研究环境， 完成OAIC总体目标所需的以脆弱性为重点的调查人员网络。这些目标将是 与生物统计学、生物机制和临床转化密切合作， 招聘核心领导人，以确保最佳设计和获得研究成功所需的核心资源。 这一核心的重要调查结果可以通过新的信息传播方案广泛传播。 本申请中提出的核心（IDC）。这一核心将引导试点工作向更深层次转化 了解脆弱的基本生物学和人口影响，并采取干预措施， 预防或治疗虚弱，从而帮助保持独立。

Pilot / Exploratory Studies Core (PESC): Project Summary The overall goal of the Pilot / Exploratory Studies Core (PESC) is to cultivate and support cutting edge pilot and exploratory studies that will advance the development of effective prevention and/or therapies for frailty and hence facilitate independence in older adults. The PESC Core leader, in close collaboration with other core leaders, set scientific goals for the next stages of frailty research, and then work to identify investigators whose expertise and career goals would be applicable to furthering our knowledge in the targeted areas. These leaders search for pilot and exploratory studies that can collect data required in order to select or design the future large-scale or confirmatory studies needed to establish frailty mechanisms, determine etiologies, or develop novel treatment and screening approaches. Studies selected for funding in the first year of this cycle include a study that pilots a behavioral intervention to concurrently address pain and frailty in older African American women, a metabolomic study that seeks to identify frailty-related metabolite signatures of energy dysregulation through a C 13 labeled glucose tolerance test, and study that seeks to further understanding of the connection between sleep disturbance and frailty by identifying specific polysomnographic signatures implicated, using functional data analysis, and exploring a potential cyclical relationship. The specific aims of the PESC are to 1) advance the science and translation of frailty research by providing intellectual leadership necessary to identify targeted areas of research and investigators that can best accomplish the translational goals of this OAIC, 2) to support the development of well-designed and informative pilot studies, 3) to provide and conduct longitudinal mentorship to supported investigators through completion of the pilot award and pursuit of funding for the next stage of research, 4) to further guide the translation of any pilot study results, and 5) to expand the research environment and network of frailty-focused investigators needed to accomplish the overall OAIC goals. These aims will be carried out in close collaboration with biostatistics, biological mechanisms, and clinical translational and recruitment core leaders to ensure optimal design and access to core resources needed for study success. Important findings from this core can be broadly disseminated through the new Information Dissemination Core (IDC) proposed in this application. This core will guide the translation of pilot work into a deeper understanding of the basic biology and population implications of frailty and into interventions that will prevent or treat frailty hence help maintain independence.