Training Program for Antiretroviral Discovery, Evaluation and Application Research (ADEAR)

项目总结 抗逆转录病毒发现、评估和应用研究培训计划是一项 综合性计划，提供人类基础、翻译和临床科学方面的多学科培训 免疫缺陷病毒1型(HIV)/获得性免疫缺陷综合征(AIDS)研究。博士后 科学家将在加州大学一群基础广泛的教员的指导下接受培训 科罗拉多、科罗拉多州立大学和丹佛大学，他们是经验丰富的导师和 积极从事与新的抗逆转录病毒药物的发现和评估有关的研究 应用现有的抗逆转录病毒药物治疗和预防艾滋病毒/艾滋病。 这项T32拨款申请将把ADEAR确立为一个新的研究培训计划，将 提供互动式博士后研究培训，培养全面发展的实验室和临床科学家 能够更好地解决结束全球艾滋病流行所需的知识差距。扶植 为ADEAR学员提供多学科研究机会，该计划聘请了经验丰富的 作为实习生导师的富有成效的艾滋病毒/艾滋病调查人员。可用于指导培训的领域 受训人员包括通过基础科学和翻译科学发现抗逆转录病毒，临床评估 抗逆转录病毒药物，以及抗逆转录病毒药物在临床和社区环境中的应用。拟议中的计划 包括以下创新功能： Thomas Campbell医学博士，一位经验丰富的临床研究员和导师，以及Mamuka Kvaratskhelia， 博士，一位经验丰富的基础科学家和导师，将担任联合项目主任。 整合的艾滋病毒临床研究人员和艾滋病毒基础/翻译科学家在计划中的途径 更好地满足不同研究背景和职业道路的学员的培训需求。 一项强有力的计划，以促进从附属机构内部和从 科罗拉多州以外的其他机构。 是一项正式计划，旨在提高项目教师的指导技能。 为促进实习生职业生涯而采取的措施，包括 个人职业发展计划；明确定义的职业发展“可交付成果”包括 研究出版物和提交K奖项申请的要求；以及提供最多3个 为学员提供多年支持，以确保有足够的时间开发K应用程序。 用于项目进度的内部和外部审查的可靠方法以及调整 培训课程，如有必要，以更好地满足学员的需求。 拟议的博士后培训计划将为培训基础和临床科学家做好准备 不同的学科，为他们的合作研究生涯做好准备，从而培养出具有 在使用抗逆转录病毒药物作为消灭艾滋病毒/艾滋病的工具方面填补知识空白所需的技能。

PROJECT SUMMARY The Training Program for Antiretroviral Discovery, Evaluation and Application Research (ADEAR) is an integrative program that provides multidisciplinary training in basic, translational and clinical science in human immunodeficiency virus type 1 (HIV)/Acquired Immunodeficiency Syndrome (AIDS) research. Postdoctoral scientist will receive training under the direction of a broadly based group of faculty at the University of Colorado, Colorado State University and the University of Denver who are who experienced mentors and actively engaged in research related to the discovery and evaluation of new antiretroviral drugs or the application of existing antiretrovirals for the treatment and prevention of HIV/AIDS. This application for T32 grant funding will establish ADEAR as a new research training program that will provide interactive postdoctoral research training to produce well-rounded laboratory and clinical scientists who are better able to address the knowledge gaps needed to end the global AIDS epidemic. To foster multidisciplinary research opportunities for ADEAR trainees, the program has engaged experienced and productive HIV/AIDS investigators as mentors for trainees. The areas of mentored training available to trainees include antiretroviral discovery through basic and translational science, clinical evaluation of antiretrovirals, and application of antiretrovirals in clinical and community settings. The proposed program includes the following innovative features:  Thomas Campbell, M.D., an experienced clinical investigator and mentor, and Mamuka Kvaratskhelia, Ph.D., an experienced basic scientist and mentor will serve as Co-Program Directors.  Integrated HIV Clinical Investigator and HIV Basic/Translational Scientist pathways within the program to better meet the training needs of trainees with diverse research backgrounds and career paths.  A robust plan to facilitate recruitment of trainees both from within the affiliated institutions and from other institutions outside of Colorado.  A formal plan to improve the mentoring skills of program faculty.  Measures to facilitate trainee careers as NIH funded independent investigators including a required individual Career Development Plan; clearly defined career development “deliverables” including research publications and requirement of submission of a K award application; and provision of up to 3 years of support to trainees to ensure sufficient time to develop a K application.  Robust methods for internal and external review of program progress and procedures for adjusting the training curriculum, if necessary, to better meet the needs of trainees. The proposed postdoctoral training program will be well equipped to train basic and clinical scientists from diverse disciplines, prepare them for collaborative research careers, and thereby produce investigators with the skills needed to fill knowledge gaps in the use of antiretrovirals as tools to end HIV/AIDS.