Training Program in NeuroHIV (TPNH)

项目总结/摘要 这是一个新的申请机构培训补助金的基本和临床方面， 由HIV引起的神经系统疾病，通常称为HIV相关的神经认知障碍 （手）。神经艾滋病毒培训计划（TPNH）正在请求支持4个高级 这些博士预科生将接受教师关于艾滋病毒如何导致神经损伤的研究培训 积极参与乔治敦大学的神经科学和免疫学项目。 这个培训计划的目的是准备科学家研究分子和细胞 神经退行性过程的机制以及引发的免疫反应 艾滋病病毒。我们的目标是培养研究人员的基础科学方面的发展 神经疗法和/或治疗策略，以减少 艾滋病病毒感染的大脑。一个由22名教师组成的经验丰富、资金充足的团队 成员具有广泛的研究兴趣和CNS功能方面的专业知识， 神经变性，病毒学和免疫学将参加博士学位。培训计划。最 学生将通过乔治敦大学跨学科项目进入研究生院 神经科学（IPN）在第一年，他们将参加课程工作，并通过轮流 潜在导师的实验室。在第二年，那些对TPNH感兴趣的人将参加 具体相关课程涉及神经退行性疾病，免疫学， HIV感染的免疫发病机制，以及扩展的综合推理和统计 扫盲培训和职业发展培训（即，论文写作和演讲技巧）。 在研究生院的第二年，学生将正式申请到TPNH与大纲 由潜在导师或共同导师批准的论文研究计划， IPN/免疫学培训学院。论文研究将在博士学位完成后开始。 在第三和第四年，学员将参加培训 与临床科学家举行会议，提供基础和临床科学方面的必要经验 这是理解HAND从实验室到治疗学的关键。学员将报告结果 从他们在年度学生研讨会上的研究，在国家会议上的演讲，以及作为 在同行评审期刊上发表文章。在公共卫生方面，该计划将创造一个 核心神经科学家培训的研究和/或管理的研究计划，通过 新的和更有效的治疗手和相关的神经免疫变性 将产生紊乱。

Project Summary/Abstract This is a new application for an Institutional Training Grant in the basic and clinical aspects of Neurological Disorders caused by HIV, better known as HIV-associated neurocognitive disorders (HAND). The Training Program in NeuroHIV (TPNH) is requesting support for 4 advanced predoctoral students who will be trained in research on how HIV causes neural injury by faculty actively participating in the Neuroscience and Immunology programs at Georgetown University. The purpose of this training program is to prepare scientists to investigate molecular and cellular mechanisms of neurodegenerative processes as well as the immunological responses triggered by HIV. Our goal is to train researchers on the basic science aspect of developing neurotherapeutics and/or treatment strategies to reduce the neuronal and glial impairments that result from HIV infection of the brain. An experienced and well-funded group of 22 faculty members with a wide range of research interests and expertise in CNS function, neurodegeneration, virology and immunology will participate in the Ph.D. training program. Most students will enter graduate school through the Georgetown University Interdisciplinary Program in Neuroscience (IPN). In the first year they will take course work and rotate through the laboratories of potential mentors. In the second year, those interested in the TPNH will take specifically relevant courses dealing with neurodegenerative disorders, immunology, and immunopathogenesis of HIV infection, as well as extended integrative reasoning and statistical literacy training, and professional development training (i.e., grant writing and presentation skills). In the second year of graduate school, students will formally apply to the TPNH with the outline of a thesis research proposal approved by a potential mentor or co-mentors from the IPN/Immunology Training Faculty. Thesis research will start after the completion of the Ph.D. program’s qualifying exam. In their third and fourth years, trainees will participate in training sessions with clinician-scientists to provide the necessary experience in basic and clinical science that is key to the understanding of HAND from bench to therapeutics. Trainees will report results from their research in yearly student seminars, presentations at national meetings, and as publications in peer-reviewed journals. With respect to public health, this program will create a core of neuroscientists trained for research and/or management of research programs, through which new and more effective treatments for HAND and related neuro-immuno-degenerative disorders will be developed.