California NeuroAIDS Tissue Network

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ABSTRACT CNTN is an active participant in the National NeuroAIDS Tissue Consortium (NNTC), a partnership of four NIH-funded neuroAIDS tissue banks. The objectives of the CNTN remain the same today as it was when it was established in 1998 and encompass 1) recruitment, clinical assessment, and follow-up of a late-stage HIV cohort, and 2) collection, maintenance, and distribution of specimens to investigators interested in conducting research on the neuropathogenesis of HIV-induced central and peripheral nervous system dysfunction. This supplement is requested to cover the difference between CNTN’s minimal essential operations and operating in-full for the supplement period (03/01/2023 - 05/31/2023). Carryforward funds have been requested to cover minimal essential operations of the CNTN for this period, with many activities substantially diminished to reduce costs. CNTN will continue to maintain an in-life cohort of approximately 150 participants with the purpose of obtaining autopsies from high priority cases that are aligned with the thematic priorities of the RFA: a) HIV eradication from CNS reservoirs; b) mechanisms of HIV-associated neurocognitive disorders (HAND) in the setting of long-term HAART, and c) understanding comorbidities associated with HIV, including the effects of aging and chronic HIV-infection. CNTN will accumulate and manage a bank of in-life (plasma, CSF, blood) and autopsy (brain, heart, lung, liver, kidney, lymph node, blood, and CSF) specimens and data from persons living with HIV who are well characterized neuropsychologically, neuromedically, and psychiatrically. CNTN will collect tissues (e.g., gut lymphoid tissue, testes) for emerging CNS cure and eradication research. Unique within the NNTC, CNTN has assumed responsibility for CNS HIV-1 Antiretroviral Therapy Effects Research (CHARTER) specimens including plasma, CSF, buccal swabs, skin biopsies, and nucleic acids. De-identified CHARTER data (clinical, laboratory, genetic, neuroimaging, and research) have been transferred to the NNTC Data Coordinating Center (DCC), where they are now maintained. CNTN maintains both CNTN and CHARTER specimen resources. External requests for de-identified CNTN or CHARTER data or specimens are managed by the DCC in collaboration with NNTC sites, and the CNTN team is well equipped to provide timely distribution of both CNTN and CHARTER specimens according to NNTC data and resource distribution policies. Finally, CNTN continues to be an active collaborating member of the NNTC by: coordinating with the DCC and other NNTC sites; providing scientific and technical expertise to the wider research community as a voting member of the NNTC Steering Committee (SC), which reviews requests for data and specimens to facilitate neuroAIDS research; and as the leader of the NNTC Neuropsychology/Psychiatry subcommittee. Through the accomplishment of these objectives, the CNTN will continue to be a national and international resource serving the needs of neuroAIDS investigators.