Texas NeuroAIDS Research Center

德克萨斯神经艾滋病研究中心

基本信息

批准号：
10818807
负责人：
BENJAMIN B. GELMAN
金额：
$ 21.68万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10818807
关键词：
Autopsy Biological Assay Biological Specimen Banks Blood Brain Budgets Cerebrospinal Fluid Client Clinic Clinical Clinical Data Communication Communities Contracts Data Data Collection Data Coordinating Center Discipline of Nursing Disparity population Economically Deprived Population Elderly Equilibrium Equipment Equipment and supply inventories Funding Future HIV HIV Seropositivity HIV/AIDS Human Institutional Review Boards Maintenance Measures Medical National NeuroAids Tissue Consortium Nervous System Neuropsychology Notification Nursing Staff Patients Population Procedures Process Repository Operations Research Research Personnel Resources Safety Schedule Services Site Source Specimen Substance abuse problem Supervision Texas Time Toxicology Transportation Travel U-Series Cooperative Agreements United States National Institutes of Health Visit Writing clinical database clinical research site cost human tissue medical schools neuroAIDS operation opioid overdose professor programs quality assurance recruit social disparities substance use virology

项目摘要

Abstract This application is for supplemental bridge funding to maintain operation of the Texas NeuroAIDS Research Center (TNRC) for a brief period of time (U24MH10093010). This project recruits HIV positive patients, characterizes them medically and neuropsychologically, performs autopsies when appropriate, maintains a human specimen repository, and distributes specimens worldwide. The funding for fiscal year 5 of this cooperative agreement U24 was to end on February 28, 2023. As of this writing the program is operating on a no cost extension combined with a pending request for “carry forward” funds from prior years that has not yet been approved. The application for continued funding via contracting is under a review by the NIH. According to federal officials the decision regarding funding in the future will not be known for approximately six months from the end of the U24. That has created a “funding gap.” Following the advice of federal officials, we are applying for supplemental bridge funding to maintain normal operations until a decision on long term funds is issued by the NIH. We were advised to apply for funds that will allow operation through August 31, 2023, which amounts to roughly six months of normal operation from the time the U24 was to end. Our request for bridge funds for that period is calculated in a manner suggested by the NIH. We have subtracted from our request two sources of potentially available funds: 1) the balance that was available for an approved no cost extension, and 2) a separate amount corresponding to a pending request for carry forward of unspent funds from prior years. Assuming that these two requests are both approved and enacted by the NIH, we calculated an amount of additional funds necessary to operate through September 1, 2023. That amount is reflected in our budget request and its justification. Supplemental funding is requested to maintain operation until the long-term plan for funding the project become clear.

抽象的该申请是为了维持德克萨斯神经辅助工具的补充桥梁资金研究中心（TNRC）短时间（U24MH10093010）。该项目招募艾滋病毒阳性患者在医学和神经心理学上对他们进行角色，在适当，维护人类标本存储库，并在全球范围内分发标本。这合作协议U24的第5财政年度的资金将于2023年2月28日结束。编写该程序正在以无费用延期进行操作，并结合待处理的请求“随身携带尚未批准的前几年的资金。继续资金的申请 NIH的审查是通过签约的。据联邦官员称，有关资金的决定从U24结束开始大约六个月，将来将不会闻名。那是创造的 “资金差距”。遵循联邦官员的建议，我们正在申请补充桥梁 NIH发行了直到长期资金的决定，以维持正常运营。我们建议申请将允许运营到2023年8月31日的资金，该资金等于从U24结束开始，大约六个月的正常运行。我们要求桥梁资金的要求在此期间，以NIH建议的方式计算。我们从我们的要求中减去潜在可用资金的两个来源：1）可用于批准的无费用的余额扩展名，以及2）单独的金额，对应于未决请求的未货前几年的资金。假设这两个请求既由NIH批准和颁布，我们计算了在2023年9月1日运营所需的额外资金。金额反映在我们的预算请求及其理由中。要求补充资金维护运营，直到为项目提供资金的长期计划。

项目成果

期刊论文数量（23）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

When do models of NeuroAIDS faithfully imitate "the real thing"?

DOI：
10.1007/s13365-017-0601-5
发表时间：
2018-04
期刊：
Journal of neurovirology
影响因子：
3.2
作者：
Gelman BB;Endsley J;Kolson D
通讯作者：
Kolson D

MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology.

DOI：
10.1371/journal.ppat.1006360
发表时间：
2017-06
期刊：
PLoS pathogens
影响因子：
6.7
作者：
Xu Z;Asahchop EL;Branton WG;Gelman BB;Power C;Hobman TC
通讯作者：
Hobman TC

Advancing our understanding of HIV co-infections and neurological disease using the humanized mouse.

DOI：
10.1186/s12977-021-00559-z
发表时间：
2021-06-16
期刊：
Retrovirology
影响因子：
3.3
作者：
Endsley JJ;Huante MB;Naqvi KF;Gelman BB;Endsley MA
通讯作者：
Endsley MA

Prefrontal dopaminergic and enkephalinergic synaptic accommodation in HIV-associated neurocognitive disorders and encephalitis.

DOI：
10.1007/s11481-012-9345-4
发表时间：
2012-09
期刊：
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
影响因子：
6.2
作者：
Gelman, Benjamin B.;Lisinicchia, Joshua G.;Chen, Tianshen;Johnson, Kenneth M.;Jennings, Kristofer;Freeman, Daniel H., Jr.;Soukup, Vicki M.
通讯作者：
Soukup, Vicki M.

Lipocalin-2 mediates HIV-1 induced neuronal injury and behavioral deficits by overriding CCR5-dependent protection.

DOI：
10.1016/j.bbi.2020.06.016
发表时间：
2020-10
期刊：
Brain, behavior, and immunity
影响因子：
0
作者：
Ojeda-Juárez D;Shah R;Fields JA;Harahap-Carrillo IS;Koury J;Maung R;Gelman BB;Baaten BJ;Roberts AJ;Kaul M
通讯作者：
Kaul M