Understanding components of mind-body exercise for physical activity engagement in metabolic syndrome

项目摘要 该K23奖项将支持候选人的培训和发展，以进行独立的临床研究。 职业生涯专注于了解身心锻炼干预机制，以优化健康 医学人群的行为促进。背景缺乏身体活动的比例高得惊人， 特别是在心脏代谢疾病患者中。身心锻炼干预措施有望 促进身体活动，因为他们参与关键的健康行为改变过程。而 身心运动干预的多维性是一种优势，它也对 了解个体治疗成分如何参与健康行为改变过程。 解开治疗成分的相对贡献对于优化身心锻炼至关重要 促进身体活动的干预措施。具体目标。以代谢综合征为模型， 本研究的目的在于：（1）改进析因设计的内容和程序，以分解两个身心 运动成分、运动和正念注意力，通过久坐患者焦点小组的反馈 与代谢综合征和一个跨学科的专家小组;（2）评估的可行性和可接受性 试验性RCT中的析因设计;（3）探索自我调节变化的组内模式， 心肺生理学和三个时间点的身体活动水平。训练候选 将接受三个方面的培训，以发展对其整体职业目标至关重要的专业知识：（1）优化- 集中的临床试验设计和实施;（2）定性研究和纵向数据分析 （3）心肺生理学研究。这些培训目标将得到广大 机构资源，以及课程、培训、研究研讨会/会议， 两会导师制。候选人将得到专家指导团队的支持：格洛丽亚叶，医学博士， MPH（主要导师），Peter韦恩，博士（共同导师），Long Ngo，博士（合作者），Chung-Kang Peng，博士 （合作者），丹尼尔福尔曼，医学博士（顾问），埃里克劳克斯，博士（顾问）和凯伦基尔戈尔，博士 （顾问）。冲击根据NCCIH的优先事项，通过K23提案获得的技能将促进 独立研究生涯专注于了解身心运动干预如何促进健康 并优化这些干预措施以促进健康。虽然最初的研究将集中在代谢 综合征和体力活动参与，从这个项目的结果将允许候选人制定一个 模型来研究其他医学人群的身心锻炼， 保持健康的行为。该K23合同将为R61/R33应用提供初步数据， 检查身心锻炼成分对健康行为改变过程的相对贡献， 这些过程的变化是否会导致身体活动参与的下游改善。

PROJECT SUMMARY This K23 award will support the candidate’s training and development for an independent clinical research career focused on understanding mechanisms of mind-body exercise interventions to optimize them for health behavior promotion in medical populations. BACKGROUND. Rates of physical inactivity are alarmingly high, particularly in patients with cardiometabolic conditions. Mind-body exercise interventions are promising for promoting physical activity because they engage key health behavior change processes. While the multidimensionality of mind-body exercise interventions is a strength, it also poses challenges for understanding how individual therapeutic components engage health behavior change processes. Disentangling the relative contribution of therapeutic components is critical for optimizing mind-body exercise interventions for physical activity promotion. SPECIFIC AIMS. Using metabolic syndrome as a model, the proposed study aims to: (1) refine the content and procedures of a factorial design to dismantle two mind-body exercise components, exercise and mindful attention, via feedback from focus groups with sedentary patients with metabolic syndrome and an interdisciplinary expert panel; (2) evaluate the feasibility and acceptability of the factorial design in a pilot RCT; and (3) explore within-group patterns of change in self-regulation, cardiopulmonary physiology, and physical activity levels across three timepoints. TRAINING. The candidate will receive training in three areas to develop expertise critical to her overall career goals: (1) optimization- focused clinical trial design and implementation; (2) qualitative research and longitudinal data analysis (mediation); and (3) cardiopulmonary physiology research. These training aims will be supported by vast institutional resources, as well as coursework, trainings, research seminars/meetings, and scientific conferences. MENTORSHIP. The candidate will be supported by an expert mentoring team: Gloria Yeh, MD, MPH (primary mentor), Peter Wayne, PhD (co-mentor), Long Ngo, PhD (collaborator), Chung-Kang Peng, PhD (collaborator), Daniel Forman, MD (consultant), Erick Loucks, PhD (consultant), and Karen Kilgore, PhD (consultant). IMPACT. In line with NCCIH priorities, skills acquired through this K23 proposal will promote an independent research career focused on understanding how mind-body exercise interventions promote health and optimizing these interventions to foster health promotion. While initial studies will focus on metabolic syndrome and physical activity engagement, findings from this project will allow the candidate to develop a model to study mind-body exercise for other medical populations known to struggle with initiating and sustaining healthy behaviors. This K23 award will provide preliminary data for a R61/R33 application to examine relative contributions of mind-body exercise components on health behavior change processes and whether changes in these processes lead to downstream improvements in physical activity engagement.