Responsible Conduct of Research Training in Biomedical Data Science for Dental, Oral and Craniofacial Research

项目摘要/摘要 这个R25教育项目建议开发一套开始口腔生物学的培训模块 研究员和牙科专科住院医生。拟议的模块将介绍 负责任地开展牙科、口腔和医学领域的生物医学数据科学研究 颅面研究。随着研究技术的快速发展，过去十年 看到了关于人类健康和疾病的大量积累的数据。生物医学数据科学是一门新兴的学科 最好地分析海量生物医学数据集以发现有关 我们的健康和疾病的功能和机制，这与我们未来的专业人员在 科学研究和临床牙科。 生物医学数据科学中的具体挑战包括适当的数据管理系统处理 以公平(可查找、可访问、可互操作和可重复使用)的方式设置数据集；标准化的科学 捕获数据转换来源的工作流系统；以及牙科领域的伦理挑战 使用数字、电子和移动健康记录的隐私、匿名、安全和知情同意。这个 建议的教育模块将通过扩展的 大规模在线课程(XMOOC)格式。 目标1：PD/PI将组成专职教员工作组，[1]管理一个高度 相关案例系列，包括牙科、口腔和颅面研究领域的内容顾问 作为生物医学数据科学；[2]设计和开发案例研究和问题集；以及[3]构建视频 加州大学洛杉矶分校教学媒体制作的剪辑。目标2：PD/PI和工作组将[1]建立 5个模块的xMOOC培训计划；[2]开发论坛和案例讨论计划；并建立自我 测试问题。加州大学洛杉矶分校教学促进中心(CAT)是帮助实现这一目标的校园资源 进程。目标3：PD/PI和工作组将[1]启动受邀受训人员的试点测试；和[2] 分析评估矩阵并进行必要的修改。 为成功开发培训模块，PD/PI和工作组将 由教育项目顾问和从富人那里征集的内容顾问提供支持 加州大学洛杉矶分校的研究环境。加州大学洛杉矶分校牙科学院院长致力于支持这一计划 发展。 最后，培训模块的最终版本将由加州大学洛杉矶分校的 促进教学，并通过非营利性MOOC提供商传播，并提交给NIGMS。

PROJECT SUMMARY/ABSTRACT This R25 educational project proposes to develop a set of training modules for starting oral biology research fellows and dental specialty residents. The proposed modules will introduce the training in Responsible Conduct of Research focusing on biomedical data science in the field of dental, oral and craniofacial research. With the advent of the rapid development of research technologies, the past decade has seen vast accumulation of acquired data on human health and diseases. The biomedical data science is a new research discipline to best analyze the massive biomedical data sets to discover new knowledge about the function and mechanism of our health and disease, which is highly relevant to our future professionals in scientific research and clinical dentistry. Specific challenges in biomedical data science include the appropriate data curation system handling the datasets in a FAIR (Findable, Accessible, Interoperable, and Reusable) manner; the standardized scientific workflow systems to capture the provenance of data transformations; and the ethical challenge in dentistry for privacy, anonymity, security and informed consent using digital, electronic and mobile health records. The proposed educational modules will discuss these challenges in real life scenarios through an extended massive online course (xMOOC) format. Aim 1: The PD/PI will form the WORKING TEAM of committed faculty to [1] curate a bank of highly relevant case series with content advisors who are established in dental, oral and craniofacial research as well as biomedical data science; [2] design and develop case studies and problem sets; and [3] construct video clips with UCLA Instructional Media Production. Aim 2: The PD/PI and the WORKING TEAM will [1] establish the 5-module xMOOC training program; [2] develop forums and case discussion programs; and establish self- test problems. UCLA Center for Advancement of Teaching (CAT) is the campus resources assisting this process. Aim 3: The PD/PI and the WORKING TEAM will [1] initiate the pilot test with invited trainees; and [2] analyze the evaluation matrix and make necessary revisions. To succeed the development of the training module, the PD/PI and the WORKING TEAM will be supported by the educational program advisors and the content advisors solicited throughout from the rich research environment of UCLA. The Dean of UCLA School of Dentistry is committed to support this program development. Finally, the final version of the training module will be professionally evaluated by UCLA Center for the Advancement of Teaching, and disseminated through a non-profit MOOC provider and submitted to NIGMS.