The Network for Investigation of Delirium: Unifying Scientists (NIDUS)'s 9th-13th Annual Delirium Boot Camps: A Foundation for Future Exploration

痴呆症是一种严重的认知障碍，与阿尔茨海默病和相关痴呆(ADRD)有关 这每年影响约260万老年人。这是一种常见的急性疾病、手术和现在的并发症 新冠肺炎在老年人中的感染。认识到精神错乱研究的相对匮乏，国家研究所 老龄化协会(NIA)支持建立妄想症调查网络：联合科学家 (NIDUS)，一个由来自27个机构的28名调查人员组成的合作跨学科小组，以推进精神错乱 研究发展网络基础设施。这包括创建一个年度“新冠训练营”。 会议，将日益增长的国内和国际精神错乱研究界聚集在一起 网络和教育。训练营的目的是促进该领域的科学发展，并为青少年提供 研究人员通过模拟NIH申请审查、临床和研究讲座进行密集指导， 分组讨论和训练营后的网络交流。为训练营校友提供以下方面的指导：1)使用 NIDUS Delirium研究中心，测量资源和书目，2)向 NIDUS试点计划(13笔一年50,000美元的赠款)，NIA GEMSSTAR/ClinStar，阿尔茨海默氏症 协会和其他基金会，3)参加辅导网络研讨会，4)参加初级教师工作 5)向美国妄想症协会(ADS)年会提交研究摘要。作为私人侦探， 94名校友获得了46项资助，其中18项(40%)是由NIH资助的，并发表了265项原创同行-- 评论文章。NIDUS已经启动了许多年轻调查人员的职业生涯，特别是训练营 校友，使他们能够启动在精神错乱研究方面的独立项目。 该应用程序的目标是支持继续每年一次的主题为Delirium BootCamp的会议 (DBC)，以确保这一活跃的研究界的进展得以持续。第一年的主题是 精神错乱与ADRD的相互关系。具体目标是：(1)吸引和支持青少年 精神错乱研究中的调查人员通过指导和接触精神障碍资源/网络(2)促进 研究人员的资助成功(3)促进了精神错乱研究的发表，并提供了持续的 指导，以及(4)促进初级、中期和高级研究人员在期间和之后建立联系 DBC。随着精神错乱调查员队伍的扩大，迫切需要召开一次会议，集中讨论 处理精神错乱研究所有领域的尖端研究方法，包括与 -OMICS研究、机器学习和大数据、随机试验的创新、动物模型和 机理研究，临床实践改进。DBC将提供一个无与伦比的机会 通过互动教学会议和深入指导推动尖端精神错乱研究 复杂和细致入微的研究方法对于最高水平和最有影响力的精神错乱研究至关重要。

Delirium is a serious cognitive disorder associated with Alzheimer’s disease and related dementias (ADRD) that affects ~2.6 million older adults yearly. It is a frequent complication of acute illness, surgery and, now, of COVID-19 infection in older adults. Recognizing the relative dearth of delirium research, the National Institute for Aging (NIA) supported the establishment of the Network for Investigation of Delirium: Unifying Scientists (NIDUS), a collaborative interdisciplinary group of 28 investigators, from 27 institutions, to advance delirium research and develop network infrastructure. This included the creation of an annual “NIDUS bootcamp” conference, to bring together the growing national- and international delirium research community for networking and education. The bootcamp aims are to advance the science of the field and to provide junior investigators with intensive mentorship, through mock NIH application reviews, clinical and research lectures, breakout sessions, and post-bootcamp networking. Bootcamp alumni are provided guidance on: 1) using the NIDUS Delirium Research Hub, Measurement resources and Bibliography, 2) submitting proposals to the NIDUS Pilot Program (13 one-year $50,000 grants awarded), NIA GEMSSTAR/CLINSTAR, the Alzheimer’s Association, and other foundations, 3) attending Mentoring webinars, 4) participating in Junior Faculty Working Groups, and 5) submitting research abstracts to the American Delirium Society (ADS) Annual Meeting. As PIs, 94 alumni have received 46 grants, of which 18 (40%) were NIH-funded, and published 265 original peer- reviewed articles. NIDUS has jumpstarted the careers of many young investigators, particularly bootcamp alumni, enabling them to launch independent programs in delirium research. The goal of this application is to support continuation of a yearly, themed Delirium Bootcamp Conference (DBC), to ensure that the progress of this active research community is sustained. The first-year theme will be the inter-relationship between delirium and ADRD. The Specific Aims are to: (1) Engage and support junior investigators in delirium research through mentorship and access to the NIDUS resources/network (2) Boost the researchers’ funding success (3) Facilitate publication of delirium research and provide ongoing mentorship, and (4) Facilitate networking among junior, mid-career, and senior researchers during and after DBC. As the pool of delirium investigators expands, there is a critical need for a conference focused on addressing cutting-edge research methods in all areas of delirium research, including the relationship with ADRD, “-Omics” research, machine learning and big data, innovations in randomized trials, animal models and mechanistic research, and clinical practice improvement. The DBC will provide an unparalleled opportunity to advance cutting-edge delirium research through interactive didactic sessions and in-depth guidance on complex and nuanced research methods essential for the highest caliber and most impactful delirium research.