Limited Competition: Continuation of the Center for Genomic Studies on Mental Disorders

项目摘要 NIMH知识库和基因组学资源（NRGR）的目标是进一步了解 精神障碍的遗传和环境病因学。NRGR接收原始生物样本，如血液， 来自NIMH支持的研究项目。NRGR将这些样品处理成DNA、RNA、cDNA或细胞 线，然后可以用于基因组分析。NRGR还接收，策划和协调 每例受试者的临床/表型数据。NRGR中样本的基因组分析结果如下： 直接存放在自然资源保护区或链接到另一个公共储存库的存款。在一个专有的 期间，临床数据，基因组数据，DNA，RNA，cDNA和细胞系可供所有NIMH- 通过一个安全的门户网站批准的研究人员。这种共享统一处理的生物样本 来自许多队列的精心策划的临床和基因组数据利用了NIMH在遗传研究方面的投资。它 通过为遗传基础的研究提供大量的数据，提供了关键的研究力量 治疗个体精神障碍自1998年10月以来，已向NRGR提交了> 25万个受试者样本 已分布> 615 K DNA和> 15 K细胞系。有超过1，700个临床分布 和基因组数据提供给> 1，000名研究人员，导致> 1，000篇使用NRGR样本和数据的出版物。 从2011年开始，NRGR为诱导多能干细胞提供了深入的表征服务 iPSC和它们的祖体细胞，以及有限的iPSC生产。作为其指导目标，NRGR将 继续创新，以灵活和高度可及的方式服务于NIMH PI的科学需求 方式，同时尊重受试者保密性、知情同意问题和PI特权。

Project Summary The goal of the NIMH Repository and Genomics Resource (NRGR) is to further the understanding of the genetic and environmental etiologies of mental disorders. The NRGR receives raw biosamples, such as blood, from NIMH-supported research projects. The NRGR processes these samples to DNA, RNA, cDNA, or cell lines, which can then be used for genomic analyses. The NRGR also receives, curates, and harmonizes clinical/phenotypic data for each subject. Results of genomic analyses on samples in the NRGR are either directly deposited in the NRGR or are linked to a deposit in another public repository. After a proprietary period, the clinical data, genomic data, DNA, RNA, cDNA, and cell lines are made available to all NIMH- approved researchers through a secure web portal. This sharing of uniformly processed biological samples and curated clinical and genomic data from many cohorts leverages the NIMH investment in genetic studies. It provides critical research power by making a very large body of data available for study of the genetic bases for individual mental disorders. Since October 1998, >250K subject samples have been submitted to NRGR and >615K DNA and >15K cell lines have been distributed. There have been >1,700 distributions of clinical and genomic data to >1,000 investigators, resulting in >1,000 publications using NRGR samples and data. Starting in 2011, the NRGR has provided in-depth characterization services for induced pluripotent stem cells (iPSC) and their progenitor somatic cells, as well as limited iPSC production. As its guiding aim, the NRGR will continue to innovate in order to serve the scientific needs of NIMH PIs in a flexible and highly accessible manner, while respecting subject confidentiality, informed consent issues, and PI prerogatives.