Center for Genomic Studies on Mental Disorders

精神疾病基因组研究中心

• 批准号: 9251973
• 负责人: Linda M Brzustowicz
• 金额: $ 102.65万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9251973
• 关键词: Automation; Bioinformatics; Biological Process; Biology; Blood; Blood Cells; California; Cell Line; Cells; Clinical; Clinical Data; Clinical Distribution; Communities; Complementary DNA; Contracts; DNA; DNA Repository; Data; Data Provenance; Data Set; Data Storage and Retrieval; Databases; Development; Disease; Epigenetic Process; Equilibrium; Etiology; Fee-for-Service Plans; Fibroblasts; Gene Expression; Genetic; Genetic Variation; Genomics; Genotype; Goals; Grant; Health; Housing; Human Genetics; Individual; Information Sciences; Informed Consent; Institutes; Instruction; Internet; Interview; Investigation; Investments; Lymphocyte; Maintenance; Mental disorders; Methodology; National Institute of Mental Health; Neurons; Phenotype; Plasma; Price; Privacy; Process; Production; Publications; Quality Control; RNA; Recovery; Research; Research Personnel; Resource Sharing; Resources; Rice; Sampling; Secure; Security; Services; Shipping; Ships; Somatic Cell; Source; Stem Cell Research; Technology; Tissue Sample; U-Series Cooperative Agreements; Universities; Washington; base; cohort; cost; data format; data integration; data management; database of Genotypes and Phenotypes; design; epigenomics; exome; flexibility; genetic analysis; genetic pedigree; genome-wide; genomic data; genomic tools; improved; induced pluripotent stem cell; innovation; lymphoblast; medical schools; next generation sequencing; novel; novel diagnostics; novel therapeutic intervention; online repository; phenotypic data; progenitor; prospective; quality assurance; repository; sample collection; stem cell differentiation; success; tool; transcriptome; transcriptomics; web site; whole genome

DESCRIPTION (provided by applicant): The goal of the NIMH Human Genetics Initiative (HGI) is to further understand the genetic and environmental etiologies of mental disorders. One of the major mechanisms for accomplishing this goal is the NIMH Center for Collaborative Genomics Research on Mental Disorders (the "Center"), which receives raw biosamples such as blood from NIMH PIs. The Center processes samples to DNA, RNA, cDNA or cell lines, which can then be submitted for genomic analyses. Along with biosamples the Center receives clinical/phenotypic data for each subject and, eventually, the results of genomic analyses. After a proprietary period, the clinical data, genomic data, DNA, RNA, cDNA and cell lines are made available to all NIMH-approved researchers through a. secure web site. This sharing of uniformly processed biological samples and clinical and genomic data from many cohorts leverages the NIMH investment in a large number of HGI grants. It provides critical research power by providing a large body of data applicable to investigations on the genetic bases for individual mental disorders. Since October 1998, >147,000 subject samples have been submitted and the Center has distributed >310,000 DNA samples and >9,000 cell lines. There have been >450 distributions of clinical and genotype data to ~340 investigators and >260 publications using these samples and data. Starting in 2011 the Center provided cell line banking and characterization services for induced pluripotent stem cells (iPSC) and their progenitor somatic cells. The Center also develops novel bioinformatics and computational genomics tools and methodologies designed to integrate and analyze large, independent sets of genotypic and phenotypic data while resolving phenotype and/or genotype discrepancies in datasets. As its guiding aim, the Center will continue to innovate in order to serve the scientific needs of NIMH PIs in a flexible and highly accessible manner, while respecting subject confidentiality, informed consent issues and PI prerogatives.

描述（由申请人提供）：NIMH人类遗传学倡议（HGI）的目标是进一步了解精神障碍的遗传和环境病因。实现这一目标的主要机制之一是NIMH精神疾病合作基因组学研究中心（“中心”），该中心接收来自NIMH PI的原始生物样本，如血液。该中心将样本处理成DNA、RNA、cDNA或细胞系，然后提交进行基因组分析。沿着生物样本，中心接收每个受试者的临床/表型数据，并最终获得基因组分析结果。经过一段时间的专有期后，临床数据，基因组数据，DNA，RNA，cDNA和细胞系通过一个。安全网站这种来自许多队列的统一处理的生物样本和临床及基因组数据的共享利用了NIMH对大量HGI赠款的投资。它通过提供大量适用于调查个体精神障碍遗传基础的数据，提供了关键的研究力量。自1998年10月以来，已提交了147 000多个受试者样本，中心分发了310 000多个DNA样本和9 000多个细胞系。已经有超过450个临床和基因型数据分发给约340名研究者，以及超过260篇使用这些样本和数据的出版物。从2011年开始，该中心为诱导多能干细胞（iPSC）及其祖细胞提供细胞系库和表征服务。该中心还开发了新的生物信息学和计算基因组学工具和方法，旨在整合和分析大型独立的基因型和表型数据集，同时解决数据集中的表型和/或基因型差异。作为其指导方针，该中心将继续创新，以服务于科学 以灵活和高度可及的方式满足NIMH PI的需求，同时尊重受试者保密性、知情同意问题和PI特权。