Childhood Asthma in Urban Settings

本研究的总体目标是提供NIAID儿童哮喘在城市环境中的临床 研究网络中心（CAUSE）拥有高度发达和经验丰富的临床研究中心（CRC） 在西奈山医疗保健系统。我们建议西奈山医疗保健系统是好的- 定位并准备创建NIAID CAUSE-CRC，以开展网络和中心特定研究 基于：1）我们成功地从城市人群中招募和保留了哮喘研究受试者; 2） 研究人员积极开展创新研究，以了解特应性疾病的机制; 3） 建立和组织良好的临床研究计划，并配备致力于开展研究的工作人员; 4） 提供设施和机构支持，以确保这一建议取得成功;以及5）高风险人口众多 在西奈山健康中心接受护理和参与研究的城市哮喘儿童/青少年 系统拟议的西奈山CAUSE-CRC包括一个具有强大背景的调查人员团队 与哮喘、过敏、免疫学、流行病学、转录组学、微生物组学和系统生物学相关， 以前合作过。Busse博士、Bunyavanich博士和Wisnivesky博士曾担任多个 NIH和PCORI赞助的哮喘和过敏性疾病网络（包括ICAC-II、III子研究）， 个人资助的研究调查哮喘自我管理的决定因素，护理差异， 气道炎症机制、组学和系统生物学。山西省政协支持。 研究者Wright博士和米勒博士在儿童哮喘网络研究中具有丰富的经验。我们 团队包括研究协调员，护士，实验室技术员，统计学家，生物信息学家， 药剂师和与研究者合作的监管成员，这将使我们能够 成功招募、实施方案、维护研究数据的完整性，并与LC协调， 合同研究组织。我们中心的特定项目1，将调查并发AD的影响 在城市儿童哮喘控制，并将进行与博士Guttman-Yassky，专家在特应性哮喘 西奈山的皮炎项目2将研究L-精氨酸/不对称二甲基 精氨酸与城市肥胖青少年哮喘发病率。我们的个人研究项目 提供了关于机制和未来治疗方法的新信息， 城市环境中患有哮喘和AD的儿童。

The overall objective of this study is to provide the NIAID Childhood Asthma in Urban Settings Clinical Research Network Center (CAUSE) with a highly developed and experienced Clinical Research Center (CRC) at the Mount Sinai Health Care System. We propose that the Mount Sinai Health Care System is well- positioned and prepared to create a NIAID CAUSE-CRC to conduct Network and Center-specific studies based upon: 1) Our success recruiting and retaining subjects in asthma studies from urban populations; 2) Investigators actively conducting innovative research to understand mechanisms of atopic diseases; 3) Established and well-organized clinical research programs with committed staff to conduct research studies; 4) Facilities and institutional support to ensure the success of this proposal; and 5) A large population of high risk urban children/adolescents with asthma who receive care and participate in research at the Mount Sinai Health System. The proposed Mount Sinai CAUSE-CRC includes a team of investigators with strong backgrounds relevant to asthma, allergy, immunology, epidemiology, transcriptomics, microbiome, and systems biology who have previously collaborated. MPIs Drs. Busse, Bunyavanich and Wisnivesky have served as PIs on several NIH and PCORI-sponsored asthma and allergic diseases networks (including ICAC-II, III sub-studies) and individually funded studies investigating determinants of asthma self-management, disparities in care, mechanisms of airway inflammation, -omics, and systems biology. The Mount Sinai CRC is supported by Co- Investigators Drs. Wright and Miller who have extensive experience in pediatric asthma network studies. Our team includes research coordinators, nurses, laboratory technicians, statisticians, bioinformaticians, pharmacists, and regulatory members who have worked with the investigators which will allow us to successfully recruit, conduct protocols, maintain the integrity of study data, and coordinate with the LC and Contract Research Organizations. Our Center-specific project 1, will investigate the influence of concurrent AD on asthma control in urban children and will be conducted with Dr. Guttman-Yassky, an expert in atopic dermatitis at Mount Sinai. Project 2 will investigate the association between L-Arginine/Asymmetric Dimethyl Arginine and asthma morbidity in obese urban adolescents with asthma. Our individual research projects provide novel information on the mechanisms and a future treatment approach with a more precise benefit in children with asthma and AD in an urban setting.