2021 Lung Development, Injury and Repair Gordon Research Conference and Gordon Research Seminar

项目总结： 2021年肺发育、损伤和修复戈登研究会议(GRC)及相关戈登 研究研讨会(GRS)将于2021年8月14日至20日在密歇根州沃特维尔山谷举行。2021年的主题 “肺GRC”是“改变呼吸医学的生物发现”。这次会议是在一个关键时刻举行的， 由于与新冠肺炎大流行相关的严重肺损伤的长期后果将会到来 成为焦点，增强了我们了解并最终抵消功能失调的修复和 严重损伤后的重塑。此外，全球范围内日益加重的肺病负担仍在继续。 有增无减，全世界每年约有400万人因慢性呼吸道疾病过早死亡， 根据世界卫生组织的数据，包括COPD、哮喘和肺纤维化。而当 对基础科学研究的投资继续加速在认识上取得实质性进展 呼吸系统疾病的分子、细胞和组织水平机制，这些发现的翻译 慢性呼吸系统疾病肺功能的早期发现和有效修复与恢复 仍然是一个主要障碍。迎接这一挑战需要整合来自多个领域的专家的知识 肺发育、分子和细胞生物学、生理学、生物工程、基质生物学以及内科医生 翻译专家沉浸在人类疾病的诊断和治疗中。这次会议将 将这些不同的专业知识聚集在一起，传播和讨论肺部领域的最新发现 发展、损伤和修复，并制定新的想法、合作和方法 需要将生物发现转化为呼吸医学的有意义的进步。一位少校 肺部GRC和GRS的重点是加强专注于肺部的科学家和临床医生的渠道 发展、损伤和修复。来自R13的资金将专门用于促进参与 妇女、任职人数不足的少数群体和残疾人，特别是毕业生举行的会议 学生、博士后研究员和早期职业调查人员。GRC的独特属性(小， 隐蔽的、未公布的数据、充足的讨论时间)和GRS(学员与同行和 高级)格式为正式和非正式的互动和协作提供了机会，这可能会 对实地产生重大和持续的影响。肺发育、损伤和修复GRC/GRS将 从而促进在认识和治疗慢性肺病方面加快进展，并有助于确保 多样化的临床医生和科学家渠道的活力和增长，能够应对日益增长的 肺部疾病。

Project Summary: The 2021 Lung Development, Injury and Repair Gordon Research Conference (GRC) and associated Gordon Research Seminar (GRS) will be held August 14-20, 2021 in Waterville Valley, NH. The theme for the 2021 Lung GRC is "Biological Discoveries to Transform Respiratory Medicine". This meeting comes at a critical time, as the prolonged consequences of severe lung injuries associated with the COVID-19 pandemic will be coming into focus, heightening our need to understand, and ultimately counteract, the dysfunctional repair and remodeling that follows severe injury. Moreover, the growing global burden of lung disease continues unabated, with some 4 million premature deaths annually worldwide attributed to chronic respiratory diseases, including COPD, asthma, and pulmonary fibrosis, according to the World Health Organization. While investments in basic scientific research continue to accelerate substantial strides forward in understanding molecular, cellular and tissue level mechanisms driving respiratory diseases, translation of these findings toward early detection and effective repair and restoration of lung function in chronic respiratory diseases remains a major barrier. Meeting this challenge requires the integration of knowledge from experts spanning lung development, molecular and cell biology, physiology, bioengineering, matrix biology as well as physicians and translational experts immersed in the diagnosis and treatment of human disease. This conference will bring this diversity of expertise together to disseminate and debate the latest findings in the fields of lung development, injury and repair, and to formulate the new ideas, collaborations and approaches that will be needed to translate biologic discoveries toward meaningful advances in respiratory medicine. A major emphasis of the Lung GRC and GRS is to strengthen the pipeline of scientists and clinicians focused on lung development, injury and repair. Funds from this R13 will be specifically targeted to promote participation in the conference by women, under-represented minorities and people with disabilities, particularly graduate students, postdoctoral fellows, and early career investigators. The unique attributes of the GRC (small, secluded, unpublished data, abundant time for discussion) and GRS (close trainee interactions with peers and seniors) formats provide an opportunity for formal and informal interactions and collaborations that are likely to have significant and sustained impact on the field. The Lung Development, Injury and Repair GRC/GRS will thus promote accelerated progress in understanding and treating chronic lung diseases, and help to ensure the vitality and growth of a diverse pipeline of clinicians and scientists capable of addressing the growing burden of lung diseases.