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中文摘要
翻译
行政和生物统计核心(核心A)的主要目标是提供必要的 业务计划和组织结构,以促进U19继续取得成功。这将是 通过协调单个项目和移植的科学和后勤问题来完成 病理学和组织成像核心(核心B)及其相互作用,以加强概念的统一性和计划 Synergy和U19作为一个整体。核心将协调两国之间的沟通和科学会议 计划主任(PD)、项目负责人(PLS)、联合调查员和核心B的领导,以促进科学研究 协作、项目交互和数据共享,这些都是U19的重要目标。核心还将共同- 通过一名生物统计师协调每个项目的数据和统计输入。它将提供 为编写报告(包括年度里程碑报告)、合规和监管提供后勤援助 问题,拨款续期,摘要和手稿提交。此外,通过提供财务监督, 核心将最大限度地负责任和有效地使用和分配资金,从而履行对 匹兹堡大学和NIAID。在执行这些功能时,核心还将允许PD、PERS、核心 B领导和合作调查人员有更多的时间来解决他们的研究目标。的另一项重要功能 核心将是协调与NIAID和NHPCSG指导委员会的沟通。
英文摘要
The principal goal of the Administrative and Biostatistics Core (Core A) is to provide the essential operational plan and organizational structure to facilitate the continued success of the U19. This will be accomplished by coordinating both scientific and logistical issues for the individual Projects and the Transplant Pathology and Tissue Imaging Core (Core B), their interactions to enhance conceptual unity and Program synergy and the U19 as a whole. The Core will coordinate communication and scientific meetings between the Program Director (PD), Project Leaders (PLs), Co-Investigators and the Leader of Core B to facilitate scientific collaboration, project interaction, and data sharing,- each important goals of the U19. The Core will also co- ordinate data and statistical input for each of the Projects through a faculty biostatistician. It will provide logistical assistance for preparation of reports (including annual milestone reports), compliance and regulatory issues, grant renewal, and abstract and manuscript submissions. Also, by providing financial oversight, the Core will maximize the responsible and efficient use and allocation of funds, thus fulfilling obligations to the University of Pittsburgh and the NIAID. In executing these functions, the Core will also allow the PD, PLs, Core B Leader and Co-Investigators more time to address their research goals. An additional important function of the Core will be to co-ordinate communication with the NIAID and NHPCSG Steering Committee.
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Regulatory immune cell therapy, promotion of tolerance and underlying mechanisms in NHP renal transplantation
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