Training and Mentoring in Neurocognitive Mechanisms of Eating Disorders

这个K24职业生涯中期研究人员奖的总体目标是以患者为导向的研究，“培训和 指导进食障碍的神经认知机制“是为了让我(乔安娜·斯坦格拉斯医学博士) 继续扩大我在进食障碍方面的临床研究和指导计划。我的作品 研究神经性厌食症(AN)的神经机制并开发基于机制的新疗法 接近了。饮食失调的一般领域，尤其是一个领域，迫切需要更多的 生物行为研究，我已经准备好在这个研究不足的领域指导有抱负的临床研究人员。 神经科学的进步为新一代临床工作创造了及时的机会 生物标志物和治疗靶点。我已经建立了一个研究计划，涉及与 世界级认知神经学家，并研究了青少年大脑和行为之间的联系 患有安氏综合症的成年人。这项工作为该领域的研究开辟了新的途径，并为许多新的合作者 一直在找我当导师。通过这次K24，我会练就更多检查大脑的技能 复杂的方法，学习认知神经科学的尖端技能，强调计算 方法，并将其应用于对An的研究。我目前资助的研究包括两个概念上的- 链接的R01研究食物选择的神经机制。这款K24将利用这项工作来支持当前 指导对象并开发新的指导机会。研究计划将作为一个平台 指导对象的发展，以及推进我的研究，以寻求未来在疾病机制方面的资金支持 和治疗。 培训计划包括参加高级研讨会，与现有的和新的合作 同事们将新的方法论应用于AN的研究，并在相关计算方面进行高级培训 科学。指导计划强调对博士后实习生(精神科住院医师和 研究员)和继续与处于不同发展水平的受训人员进行努力：博士前受训人员 (医学生)和初级教职员工。希望通过我的活动，加深对 AN的神经生物学基础将得到改善，这些机制方面的进展将带来机会 用于开发新的治疗方法。我将通过我的研究和合作为这些进步做出贡献 与同事，以及通过我对未来临床研究人员的培训。

The overall aim of this K24 Mid-Career Investigator Award in Patient-Oriented Research, “Training and Mentoring in Neurocognitive Mechanisms of Eating Disorders,” is to allow me (Joanna Steinglass MD) to continue to expand my programmatic line of clinical research and mentoring in eating disorders. My work examines the neural mechanisms of Anorexia Nervosa (AN) and develops mechanism-based novel treatment approaches. The field of eating disorders in general, and AN in particular, has an urgent need for more biobehavioral research, and I am well poised to mentor aspiring clinical investigators in this understudied field. Advances in neuroscience create a timely opportunity for a new generation of clinical work identifying biomarkers and treatment targets. I have built a program of research that involves close collaboration with world-class cognitive neuroscientists, and examines the link between brain and behavior in adolescents and adults with AN. This work has opened new avenues of research for the field, and numerous new collaborators have sought my mentorship. Through this K24, I will develop the skills to examine the brain in more sophisticated ways, learning cutting edge skills in cognitive neuroscience, emphasizing computational approaches, and applying them to the study of AN. My currently funded research includes two conceptually- linked R01s examining neural mechanisms of food choice. This K24 will leverage that work to support current mentees and develop new mentorship opportunities. The Research Plan will serve as a platform for the development of mentees, and for advancing my research to pursue future funding in mechanisms of illness and treatment. The training plan includes participation in advanced seminars, collaborations with established and new colleagues to apply new methodologies to the study of AN, and advanced training in relevant computational science. The Mentoring Plan emphasizes new efforts with post-doctoral trainees (psychiatric residents and fellows) and continuation of efforts with trainees at various levels of development: pre-doctoral trainees (medical students), and junior faculty. Through my activities it is hoped that the understanding of the neurobiological underpinnings of AN will improve, and these advances in mechanism will lead to opportunities for development of new treatments. I will contribute to these advances through my research and collaborations with colleagues, and through my training of future clinical investigators.