Administrative Core

管理核心-项目摘要/摘要 寨卡病毒的快速和爆炸性传播使人们认识到怀孕期间的感染 会导致先天性寨卡病毒综合症。这项计划项目的关键假设是 孕期母体病毒血症预示着先天性寨卡病毒综合征的风险。我们将对此进行探索 通过三个综合项目提出假设。行政(管理)核心负责协调- 创建整个计划项目的活动，以确保及时有效地完成总体计划 科学目标。行政核心的活动大致分为五个具体目标： 具体目标1.协调所有参与者之间的沟通。 具体目标2.确保和维持法规遵从性。 具体目标3.管理项目财务和监督分项奖励。 具体目标4.执行与科学严谨性、透明度、数据共享和一致性有关的政策 藐视决议。 具体目标5.促进学生和初级科学家的专业发展 此计划项目。 寨卡病毒对整个美洲的孕妇及其胎儿/新生儿都是危险的。这一风险 将持续至少几年，即使它最终被自然免疫力和广泛的 接种疫苗。管理核心将协调所有项目，以确保完成所有科学 目标，为孕妇及其保健提供者提供重要的新工具以进行评估，以及 潜在地降低了先天性寨卡病毒综合症的风险。

Admin Core - Project Summary/Abstract The rapid and explosive spread of Zika virus has lead to the recognition that infection during pregnancy can lead to congenital Zika syndrome. The key hypothesis of this Program Project is that prolonged maternal viremia during pregnancy predicts the risk of congenital Zika syndrome. We will explore this hypothesis through three integrated projects. The Administrative (Admin) Core is charged with coordi- nating activities of the entire Program Project to ensure timely and efficient completion of the overall scientific goals. The activities of the Admin Core are broadly divided into five Specific Aims: Specific Aim 1. Coordinating communications between all participants. Specific Aim 2. Ensuring and maintaining regulatory compliance. Specific Aim 3. Managing program finances and overseeing subawards. Specific Aim 4. Enforcing policies pertaining to scientific rigor, transparency, data sharing, and con- flict resolution. Specific Aim 5. Promoting professional development of students and junior scientists participating in this Program Project. ZIKV is dangerous to pregnant women and their fetuses/neonates throughout the Americas. This risk will persist for at least several years, even if it is eventually curtailed by natural immunity and widespread vaccination. The Admin Core will coordinate all the Projects to ensure completion of all the scientific goals, providing important new tools for pregnant women and their healthcare providers to assess, and potentially reduce, the risk of congenital Zika syndrome.