Clinical Orthopaedic and Musculoskeletal Education and Training Program (COMET)

肌肉骨骼(MSK)和矫形外科疾病令人震惊地普遍存在，使人丧失能力，而且代价高昂 占美国国内生产总值的5%。临床骨科和肌肉骨骼学 教育和培训)T32培训计划的重点是培训临床研究人员，以解决 通过严格的临床研究，MSK疾病在全国和全球范围内的负担越来越大。彗星计划 在最初的十年里非常成功；它的25名毕业生中有21人留在了学术岗位上， 8个获得职业发展奖(5个K-Level奖和3个风湿学研究基金会职业 发展奖)和5个R级赠款(3个R01和2个R21)。这25名毕业生出版了112本 基于他们的T32资助工作的同行评议论文。近70%的现任和前任实习生是女性 3个属于代表性不足的少数群体。 在这次竞争性更新重新提交中，我们建议将重点放在6个研究培训上 集中精力，代表迫切的研究需要，并利用教员的力量：锻炼和 体力活动；骨科手术结果；创新的非药物试验；基于价值的护理；工作 和MSK障碍；以及资源有限环境中的MSK健康。受训人员解决了这些问题和相关研究 主题涉及范围广泛的MSK和骨科疾病，包括骨关节炎、骨质疏松症、 区域性疾病(脊柱、膝盖、肩部、上肢、足部/脚踝)、骨科创伤、关节和软组织 问题、神经卡压、慢性疼痛及相关情况。通过他们的彗星训练，杨 研究人员在生物统计学和流行病学以及其他一系列学科中获得关键技能 基于他们的职业兴趣(例如，行为科学、经济分析、临床试验)。实习生没有 事先接受过这些方法的正规教学培训，获得临床有效性硕士学位 哈佛大学公共卫生学院的研究项目。杰弗里·卡茨博士和埃琳娜·洛西娜博士执导 Comet计划，并得到经验丰富、富有成效和协作精神的教职员工团队的支持 来自哈佛大学医学界和公共卫生界的导师。此应用程序请求提供资金 每年两个博士后培训职位和三个博士后培训职位。此续订重新提交申请 建立在该计划第一个十年成功的基础上，并由总体目标驱动 促进研究以提高MSK病症患者的生活质量。

Musculoskeletal (MSK) and orthopaedic disorders are staggeringly prevalent, disabling, and costly, accounting for ~5% of gross domestic product in the US. The COMET (Clinical Orthopaedic and Musculoskeletal Education and Training) T32 training program is focused on training clinical researchers to address the growing national and global burden of MSK disorders through rigorous clinical research. The COMET program has been highly successful in its first decade; 21 of its 25 graduates have remained in academic positions, with 8 receiving career development awards (5 K-level awards and 3 Rheumatology Research Foundation career development awards), and 5 R-level grants (3 R01s and 2 R21s). These 25 graduates have published 112 peer-reviewed papers based on their T32-funded work. Nearly 70% of current and former trainees are women and 3 belong to underrepresented minority groups. In this competitive renewal resubmission, we propose a programmatic focus on 6 research training concentrations that represent pressing research needs and draw on the strengths of the faculty: exercise and physical activity; orthopedic surgical outcomes; innovative non-pharmacologic trials; value-based care; work and MSK disorders; and MSK health in resource-limited settings. Trainees address these and related research themes in relation to a broad range of MSK and orthopaedic disorders, including osteoarthritis, osteoporosis, regional disorders (spine, knee, shoulder, upper extremity, foot/ankle), orthopaedic trauma, joint and soft tissue problems, nerve entrapments, chronic pain, and related conditions. Through their COMET training, young investigators acquire critical skills in biostatistics and epidemiology along with a range of other disciplines based on their career interests (e.g. behavioral science, economic analysis, clinical trials). Trainees without prior formal didactic training in these methodologies obtain a master's degree in the Clinical Effectiveness Program at the Harvard T.H. Chan School of Public Health. Drs. Jeffrey Katz and Elena Losina direct the COMET program and are supported by a highly experienced, productive, and collaborative group of faculty mentors from throughout the Harvard medical and public health communities. This application requests funding for two predoctoral and three postdoctoral training positions per year. This renewal resubmission application builds upon a foundation of success over the first decade of the program and is driven by the overarching goal of facilitating research to improve the quality of life of persons with debilitating MSK disorders.