Center on Intersystem Regulation by Drugs of Abuse

NIDA P30核心中心名为“滥用药物系统间调节中心”，提供 杰出的科学专业知识和资源，以促进研究 成瘾研究的生产力和创新。该中心已被证明是一个催化剂， 跨学科研究，并创造了来自不同学科的研究人员之间的协同作用。的 在这五年的更新中，中心的主要主题包括：1） 成瘾和具有治疗潜力的新靶点的鉴定; 2）滥用药物对 HIV感染; 3）神经免疫相互作用，包括经典神经递质之间的串扰 系统和趋化因子/细胞因子与成瘾、疼痛、炎症和HIV有关; 4）疼痛和 镇痛，目的是确定阿片类药物保留治疗疼痛。研究是在一个 广泛的物质，包括阿片类物质、大麻素、精神兴奋剂、尼古丁和酒精。 该中心由五个研究支持核心组成：成瘾相关行为的动物核心， 生化药理学核心，细胞和免疫学核心，综合生理系统和 疼痛核心，和分子生物学核心，除了行政和试点项目核心。 核心人员为中心带来了广泛的专业知识，以解决科学问题 与药物滥用、成瘾、疼痛和艾滋病毒有关的研究 协同作用。Temple P30中心的这一独特之处鼓励合作， 超越单一学科，以解决新的假设，并显着加快进展， 个人研究计划。提出了几种新的最先进的方法的实施 在这次更新申请中，这将为中心增加主要优势。NIDA P30核心中心将 提供尖端技术，以扩大NIH资助的研究项目的影响， NIDA的使命通过全国范围内的合作。此外，研究培训和指导的早期 职业科学家将继续发挥重要作用。该中心将作为国家资源 鼓励创新的科学发现，这将导致新的知识，以承担物质 虐待

The NIDA P30 Core Center, entitled “Center on Intersystem Regulation by Drugs of Abuse”, provides outstanding scientific expertise and resources to NIH investigators in order to advance research productivity and innovations in addiction research. The Center has proven to be a catalyst for interdisciplinary studies and has created synergy between investigators from diverse disciplines. The major themes of the Center that will be pursued in this 5 year renewal include: 1) mechanisms of addiction and identification of novel targets with therapeutic potential; 2) effects of drugs of abuse on HIV infection; 3) neuroimmune interactions, including cross-talk between classical neurotransmitter systems and chemokines/cytokines as related to addiction, pain, inflammation and HIV; 4) pain and analgesia with the goal of identifying opioid-sparing treatments for pain. Research is carried out on a broad spectrum of substances including opioids, cannabinoids, psychostimulants, nicotine and alcohol. The Center consists of five Research Support Cores: The Animal Core for Addiction Related Behaviors, Biochemical Pharmacology Core, Cell and Immunology Core, Integrated Physiological Systems and Pain Core, and the Molecular Biology Core, in addition to the Administrative and Pilot Project Cores. The Core personnel bring to the Center a broad array of expertise to address scientific questions related to drugs of abuse, addiction, pain and HIV from multiple approaches leading to research synergy. This unique aspect of the P30 Center at Temple encourages collaborations that extend beyond a single discipline to address novel hypotheses and significantly accelerate the progress of individual research programs. Implementation of several new state-of-the-art approaches are proposed in this renewal application that will add major strengths to the Center. The NIDA P30 Core Center will provide cutting-edge technologies to expand the impact of NIH-funded research projects related to NIDA's mission through collaborations nation-wide. In addition, research training and mentoring of early career scientists will continue to be an important function. The Center will serve as a national resource to stimulate innovative scientific discoveries that will result in new knowledge to bear on substance abuse.