Human Tissue Repository and Tissue Analysis Shared Resource

人体组织库与组织分析共享资源 摘要 新墨西哥大学人类组织信息库和组织分析(HTR-TRANSPORT)共享资源 癌症中心与UNM合作创建并共同支持的共享资源 病理学系，通过提供基本和复杂的人类生物标本来支持癌症研究 组织学服务，先进的免疫组织化学(IHC)和原位杂交(ISH)技术 高性价比、高效率、高品质的工作方式。资源标本包括新鲜的、冷冻的和固定的福尔马林， 石蜡包埋(FFPE)肿瘤和匹配的正常组织和血液和其他液体样本。标本 来源包括资源人员收集的样本，来自分布式银行的样本现在被吸收到 资源，以及通过虚拟银行网络提供的资源。资源准备最高质量 通过定期、随机的RNA和DNA测试以及病理学家对所有质量的审查进行评估的样本 控制幻灯片。资源技术人员还通过提供实时预期新鲜度来协助联合国排雷行动中心调查人员 为特定协议量身定做的样本收集。访问存档的临床医院病理FFPE组织是 通过资源进行传递，以简化临床块和幻灯片检索/返回，从而能够快速交付到联合国排雷行动 调查人员。因为根据UNM机构审查委员会(IRB)，资源是一个“诚实的中间人”， 样品可以被取消识别或匿名，从而消除了IRB审查的要求。此选项可用于 将人体样本转换为非人类受试者的研究节省了相当多的时间，同时最佳地保护了 HIPAA标识符。该资源符合NCI关于生物样品资源的最佳实践。合规性 由严格的质量控制程序和质量保证程序组成，正式的组织优先委员会 审查样本发布、安全数据管理和独立监督存储库的流程。自.以来 之前的2010年竞争对手NCI P30 CCSG续订，该资源已显著超过其声明的目标 收集10,000份冷冻和FFPE研究标本，目前拥有25,000份冷冻生物标本和7,000份冷冻生物标本 FFPE块，其收集的乳腺癌、前列腺癌和其他癌症标本显著增加。这个 资源在人员、收藏、功能和设施方面有了实质性的增长，并转移到了新的 翻新后的更大的实验室和冷藏室。通过新墨西哥州大学和新墨西哥州大学之间的一项新协议 最大的私立医院系统，该资源将获得70%新墨西哥州人的癌症样本 并将大幅增加其银行活动，获得额外的1000个癌症样本 每年一次。帐单和使用数据是电子化和集中化的。在上一个5年项目期内，36 联发团4个研究方案的成员使用了该资源，共出版了21份出版物， 其中有4个国家目前正在处理私营部门间化学品管制ID。在报告的2013年7月至2014年6月期间，联东特派团成员 占总资源使用量的85%，并得到106项同行审查赠款的支持。

HUMAN TISSUE REPOSITORY & TISSUE ANALYSIS SHARED RESOURCE ABSTRACT The Human Tissue Repository and Tissue Analysis (HTR-Tissue) Shared Resource, a University of New Mexico Cancer Center (UNMCC) Shared Resource created in collaboration with and jointly supported by the UNM Department of Pathology, supports cancer research by providing human biospecimens, basic and complex histology services, and advanced immunohistochemistry (IHC) and in-situ hybridization (ISH) technologies in a cost-effective, efficient, high quality manner. Resource specimens comprise fresh, frozen, and formalin-fixed, paraffin-embedded (FFPE) tumors and matching normal tissues and blood and other fluid samples. Specimen sources include samples collected by Resource personnel, samples from distributed banks now absorbed into the Resource, and those available through a virtual network of banks. The Resource prepares the highest quality samples as assessed by regular, randomized RNA and DNA testing and by pathologist review of all quality control slides. Resource technologists also assist UNMCC investigators by providing real-time prospective fresh sample collection tailored for specific protocols. Access to archived clinical hospital pathology FFPE tissues is routed through the Resource to simplify clinical block and slide retrieval/return enabling quick delivery to UNMCC investigators. Because the Resource is an “honest broker” per the UNM Institutional Review Board (IRB), samples may be de-identified or anonymized, thereby removing the requirement for IRB review. This option to convert human samples to “non-human subjects” research saves considerable time while optimally safeguarding HIPAA identifiers. The Resource complies with the NCI Best Practices for Biospecimen Resources. Compliance comprises rigorous quality control and quality assurance procedures, a formal tissue prioritization committee review process for sample release, secure data management, and independent oversight of the repository. Since the prior 2010 competitive NCI P30 CCSG renewal, the Resource has significantly surpassed its stated goal of collecting 10,000 frozen and FFPE research specimens and now holds >25,000 frozen biospecimens and >7,000 FFPE blocks, with a significant increase in its collection of breast, prostate, and other cancer specimens. The Resource has substantially grown in staff, collections, capabilities, and facilities, with a move to a newly renovated, larger laboratory and freezer rooms. Through a new agreement between UNM and New Mexico's largest private hospital system, the Resource will have access to cancer samples from >70% of New Mexicans and will substantially increase its banking activities, with access to an additional 1,000 cancer specimens annually. Billing and usage data are electronic and centralized. During the previous 5-year project period, 36 UNMCC members from 4 UNMCC Research Programs used the Resource, resulting in a total of 21 publications, of which 4 are presently pending PMCIDs. In the reporting year of July 2013 – June 2014, UNMCC members were responsible for 85% of total Resource usage and were supported by 106 peer-reviewed grants.