Tissue Core

项目摘要 组织核心（TC）是Moffitt癌症中心（MCC）的中央生物储存库。于1992年开业， 技术中心的总体目标是收集、处理、储存和发布高质量、注释良好的生物标本，以支持 基础、人口、临床和转化研究。MCC的TC生物库活动有三个最重要的方面 具体目标： 1.作为一个集中的MCC生物库资源，用于收集、处理和储存人类 支持成员科学的生物标本; 2.实施生物储存库最佳实践和质量指标，确保成员获得高质量的 生物标本; 3.制定和推广政策、指导方针和程序，以促进成员有效地获得人力资源。 以符合法规的方式收集生物样本。 TC位于一个2，800平方英尺的设施中，由20名训练有素的生物储存专家，工作人员 科学家、研究病理学家和经理，共同支持由实验室驱动的研究， 一般银行业务。技术合作服务由三个不同的部门提供：接收和采购、样品 处理实验室和研究组织学服务。这三个科共为206个项目提供支助， 2015财年（FY 15）。食物环境卫生署提供多种服务，例如收集 冰冻组织，普通组织学，免疫组织化学，核酸提取，组织芯片构建 (TMA)，并发布存档的生物标本。此外，为支持由专家推动的研究，技术委员会 将特定需求和应用纳入项目特定的SOP，其中通常包括促进 研究设计和采集策略，以优化生物样本处理。总的来说，TC提供了81种不同的 生物库和生物样本库相关服务，满足或超过NCI最佳实践建议， 美国病理学家（CAP）生物储存库认证标准，以确保高质量的生物标本 通过标准化、文件化和强调质量来验证收集和处理 管理除了在过去五年中为173份出版物提供资料外，过渡委员会的高质量 生物库基础设施在MCC的成功肺孢子，皮肤孢子，BMaP-3，TCGA， CPTAC提交的材料。在前一时期，过渡委员会向成员提供了大量支持， 年均近73，000个服务单位，2015财年的使用量创纪录，达到85，708个服务单位 单位在2015财年，分布在所有五个CCSG计划中的86个成员使用了TC服务，其中78%的成员使用了TC服务。 同行评审资助成员的总使用量。

PROJECT SUMMARY The Tissue Core (TC) serves as the central biorepository for Moffitt Cancer Center (MCC). Opened in 1992, the overall goal of the TC is to collect, process, store, and release high-quality, well-annotated biospecimens in support of basic, population, clinical, and translational research. TC biobanking activities at MCC have three foremost specific aims: 1. Serve as a centralized MCC biobanking resource for the collection, processing, and storage of human biospecimens in support of member science; 2. Implement biorepository best practices and quality metrics that ensure members' access to high quality biospecimens; 3. Develop and promote policies, guidelines, and procedures that facilitate members' efficient access to human biospecimens in a regulatory-compliant manner. The TC is housed in a 2,800 square foot facility and staffed by 20 highly trained Biorepository Specialists, Staff Scientists, a Research Pathologist, and a Manager that collectively support investigator-driven studies and the general banking operations. TC services are housed within three distinct sections: Intake & Acquisition, Sample Processing Lab, and Research Histology Services. Collectively, the three sections provided support for 206 protocols during fiscal year 2015 (FY15). The TC provides a wide variety of services such as collection of fresh frozen tissue, general histology, immunohistochemistry, nucleic acid extraction, construction of tissue microarrays (TMA), and release of archived biospecimens. Moreover, in support of investigator-driven studies, the TC incorporates specific needs and applications into project-specific SOPs, which often include contributing to the study design and collection strategies to optimize biospecimen handling. Overall, the TC offers 81 distinct biobanking and biospecimen-related services that meet or exceed NCI best practice recommendations and College of American Pathologists (CAP) Biorepository Accreditation standards to ensure high-quality biospecimen collection and processing validated through standardization, documentation, and emphasis on quality management. In addition to contributing to 173 publications during the past five years, the TC's high-quality biobanking infrastructure was instrumental in MCC's successful Lung SPORE, Skin SPORE, BMaP-3, TCGA, and CPTAC submissions. During the prior period, the TC provided significant support to members, demonstrated by a yearly average of nearly 73,000 service units, with FY15 representing a record year of usage with 85,708 service units. In FY15, TC services were utilized by 86 members distributed across all five CCSG programs, with 78% of total usage by peer-review-funded members.