Leveraging Big Data and Deep Learning to Develop Next Generation Decision Support Tools to Improve Glycemic Outcomes in Type 1 Diabetes

项目摘要 1型糖尿病（T1 D）的标志是胰腺β细胞分泌胰岛素不足， 功能障碍大多数人通过每日多次注射胰岛素或使用 胰岛素泵有几个决策支持智能手机应用程序可以帮助人们估计胰岛素 剂量基于连续葡萄糖监测仪（CGM）数据和食物摄入量。更复杂的决策支持 这些工具采用人体生理学的数学模型来预测未来的葡萄糖水平， 一般胰岛素治疗建议。锻炼是长期管理的重要组成部分 然而，许多人因为害怕低血糖（< 70 mg/dL）而避免体力活动。尽管协商一致 虽然有指导方针帮助人们在体力活动期间管理葡萄糖，但人们仍然会出现急性 并发症有氧运动的数学模型预测低血糖的承诺， 控制的临床实验，但在现实世界中或在其他类型的运动中表现不佳。 迫切需要一种帮助T1 D患者维持安全血糖水平的决策支持系统 围绕不同类型的运动。这个提案的目标是开发一个决策支持工具来帮助人们 使用CGM的T1 D患者可以更好地管理运动时的血糖。这个工具将被称为AIDES， 智能糖尿病运动支持系统我们假设使用一种新的练习- 特定的决策支持工具，由预测生理建模，人工智能（AI）和 深度学习，可以提供治疗建议，以减少低血糖事件的数量 T1 D患者在定期体育锻炼中所经历的。在我们的第一个目标中，我们将开发一种新的 描述胰岛素和非胰岛素介导的对葡萄糖影响的抗阻运动模型 动力学然后，我们将创建一个新的混合计算框架，利用AI来增强 有氧运动和抗阻运动的生理模型。这个混合框架，称为physAI，将利用真实的- 来自T1 Dexi项目（大数据）的自由生活运动数据。在我们的第二个目标中， 数十年的深度学习研究与T1 Dexi项目提供的大数据，以训练基于AI的 决策支持系统，提供治疗建议，以帮助用户在治疗期间维持目标葡萄糖 锻炼的在我们的第三个目标中，我们将评估我们的决策支持引擎的安全性和可用性， 由申办者支持的人类参与者概念验证研究。这将是第一个决定 专门设计的支持系统，提供治疗建议，帮助用户保持安全 葡萄糖水平，同时进行有氧运动和阻力运动。

Project Summary The hallmark of type 1 diabetes (T1D) is insufficient insulin production caused by pancreatic beta cell dysfunction. Most people treat their T1D through multiple daily injections (MDI) of insulin or use of a transcutaneous insulin pump. Several decision support smartphone apps exist to help people estimate insulin doses based on continuous glucose monitor (CGM) data and food intake. More sophisticated decision support tools employ mathematical models of human physiology to predict future glucose levels and provide generalized insulin therapy recommendations. Exercise is a crucial component of the long-term management of T1D, however many people avoid physical activity for fear of hypoglycemia (< 70 mg/dL). While consensus guidelines exist to help people manage glucose during physical activity, people still experience acute complications. Mathematical models of aerobic exercise yield promise in predicting hypoglycemia during controlled in- clinic experiments but do not perform well in the real-world or during other types of exercise. There is a critical need for a decision support system that helps people with T1D maintain safe glucose levels around exercise of varying types. The goal of this proposal is to develop a decision support tool to help people with T1D who utilize CGM better manage their glucose surrounding exercise. This tool will be called AIDES, the Artificially Intelligent Diabetic Exercise Support system. We hypothesize that use of a novel exercise- specific decision support tool, powered by predictive physiological modelling, artificial intelligence (AI), and deep learning, can provide treatment recommendations to reduce the number of hypoglycemic events experienced by people with T1D around regular physical exercise. In our first aim, we will develop a new model of resistance exercise that describes both insulin- and non-insulin mediated effects on glucose dynamics. We will then create a novel hybrid computational framework that harnesses AI to augment physiology models of aerobic and resistance exercise. This hybrid framework, called physAI, will harness real- world, free-living exercise data from the T1Dexi project (Big Data). In our second aim, we will leverage decades of research into deep learning with the Big Data provided by the T1Dexi project to train an AI-based decision support system that gives treatment recommendations to help users maintain target glucose during exercise. In our third aim, we will assess the safety and usability of our decision support engine in a small proof-of-concept study with human participants, supported by the Sponsor. This will be the first decision support system specifically designed to provide treatment recommendations that help users maintain safe glucose levels while performing aerobic and resistance exercise.