FASEB's The Lysophospholipid and Related Mediators Conference: From Bench to Clinic

摘要 FASEB溶血磷脂和相关介质科学研究会议：从实验室到临床 将于2021年7月11日至7月16日在爱尔兰的大酒店马拉希德举行。本次会议将讨论当前 研究和新兴概念主要涉及溶血磷脂鞘氨醇1-磷酸（S1 P）， 溶血磷脂酸（LPA）及其在健康和疾病中的作用。S1 P和LPA是信号脂质， 5和6 G蛋白偶联受体，并结合细胞内的靶蛋白，以调节细胞生物学。 这些生物相互作用控制心血管系统、免疫系统和免疫系统中的重要功能。 神经系统这些脂质在肺纤维化、动脉粥样硬化、癌症、自身免疫和 其他疾病状态。调节溶血磷脂代谢的受体和酶都被证明是 作为潜在的治疗靶点来诊断、预防或治疗疾病。会议将强调， 将这项工作转化为临床实践，并强调正在迅速取得的研究进展， 许多新的研究人员在这个领域。会议为来自世界各地的科学家提供了一个独特而宝贵的论坛。 不同的学科，以满足和讨论他们的最新研究成果。会议的目的是：（1）提供 来自溶血磷脂多学科的科学家和学员之间的智力交流 研究; 2）鼓励和促进早期职业和新研究者之间的积极讨论， 通过互动职业研讨会和多种网络/合作机会建立科学家; 提供一个平台，促进妇女和代表性不足的少数群体的参与。会议 将允许不同的早期职业和既定的研究人员交流最新的研究成果， 促进未来的相互作用，与开发溶血磷脂发挥作用的疾病的治疗方法相一致。 主导作用。在爱尔兰的会议地点将有助于欧洲科学家最大限度地参与， 来自国外其他国家的科学家和美国同行，以促进富有成效的互动，重点是 溶血磷脂的翻译意义。

Abstract The FASEB Science Research Conference on Lysophospholipid and Related Mediators: From Bench to Clinic will be held July 11 - July 16, 2021 at the Grand Hotel Malahide, Ireland. This conference will address current research and emerging concepts related primarily to the lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) and their roles in health and disease. S1P and LPA are signaling lipids that activate 5 and 6 G protein-coupled receptors, respectively, and bind to intracellular target proteins to regulate cell biology. These biological interactions control vital functions in the cardiovascular system, the immune system, and the nervous system. These lipids are important in pulmonary fibrosis, atherosclerosis, cancer, autoimmunity, and other disease states. Both receptors and enzymes regulating lysophospholipid metabolism have been shown to function as potential therapeutic targets to diagnose, prevent or treat disease. The conference will emphasize the translation of this work into clinical practice and highlight the research advances being made at a rapid pace by many new investigators in this field. The meeting provides a unique and invaluable forum for scientists from diverse disciplines to meet and discuss their latest research findings. The conference aims are to 1) provide intellectual exchange between scientists and trainees from multiple disciplines engaged in lysophospholipid research; 2) encourage and facilitate active discussion between early career and new investigators and established scientists via interactive career workshops and multiple opportunities for networking/collaboration; and 3) provide a platform to promote the participation of women and underrepresented minorities. The conference will allow diverse early career and established investigators to communicate late-breaking research results and promote future interactions aligned with developing therapies for diseases in which lysophospholipids play a predominant role. The conference site in Ireland will facilitate maximum participation of European scientists, scientists from other countries abroad, and US counterparts to promote productive interactions focusing on the translational implications of lysophospholipids.