Understanding the role of prenatal chemical exposure influences on child externalizing behaviors: Incorporating genetic influences

项目摘要/摘要 儿童时期的外化行为不利于建立亲社会的联系，在学业上， 保持积极的心理健康。因此，确定增加儿童罹患癌症风险的因素至关重要。 外化行为。产前接触化学物质(如邻苯二甲酸盐、有机磷农药、铅) 与儿童外化行为的风险增加有关。然而，这些工作中的大部分 考察了单一化学物质暴露的影响，考虑到现实生活中的产前的研究较少 此外，儿童基金会还注意到，儿童同时接触多种化学品可能会加剧儿童发育的风险。 此外，在很大程度上，研究忽视了遗传风险和基因环境的重要性。 相互影响。基因知情的设计有可能有助于我们理解 产前化学物质可能影响儿童行为的机制。目前的提案将解决 这些文献中的差距，利用现有的两项关于儿童发展的纵向研究， 西奈半岛儿童环境健康研究，以及行为和情绪发展的双胞胎研究- 孩子。该研究会的研究目标是：(1)使用以人为中心的潜在侧写分析方法， 为了研究产前接触化学物质的方式如何增加外化行为的风险 纵向多民族孕妇队列，以及(2)使用基因知情设计，以检查 产前化学物质暴露如何缓解弱势儿童外化行为的病因 双胞胎样本。这项拟议的研究金的跨学科方法将完善一个概念模型， 综合遗传和产前环境对儿童外化行为的影响。 拟议的研究金将提供额外培训，以：(1)获得环境流行病学方面的经验； (2)获得曝光混合物建模的经验；(3)开发一个完整的概念模型，以 产前环境调节遗传和环境对儿童社会发展的影响， (4)加强网络、研究传播和赠款写作技能，以及(5)在以下方面获得额外培训 负责任的研究行为。这项奖学金将加强我现有的社会背景培训 儿童行为发展，重点研究和培训环境流行病学和行为学 遗传学。因此，这项工作将支持我成为一名独立研究员的职业目标 多个领域的交叉对理解儿童行为发展(发展)至关重要 心理学、环境流行病学和行为遗传学)。

Project Abstract/Summary Externalizing behaviors in childhood are detrimental to building prosocial connections, achieving academically, and maintaining positive mental health. Therefore, it is crucial to identify factors that increase children’s risk for externalizing behaviors. Prenatal chemical exposures (e.g., phthalates, organophosphorus pesticides, lead) have been associated with increased risk for child externalizing behaviors. However, much of this work examines the influence of single chemical exposures, with less research considering the real-life prenatal context of simultaneous exposures to multiple chemicals that could compound risk for child development. Moreover, to a large extent, studies have ignored the importance of genetic risk and gene-environment interplay. Genetically informed designs have the potential to contribute to our understanding of the mechanisms by which prenatal chemicals may influence child behavior. The current proposal will address these gaps in the literature, making use of two existing longitudinal studies of child development, The Mount Sinai Children’s Environmental Health Study, and the Twin Study of Behavioral and Emotional Development – Child. The research goals of this fellowship are: (1) Using a person-centered, Latent Profile analytic approach, to examine how patterns of prenatal chemical exposures increase risk for externalizing behaviors in a longitudinal multiethnic cohort of pregnant women, and (2) Using a genetically informed design, to examine how prenatal chemical exposure moderates the etiology of child externalizing behaviors in a disadvantaged twin sample. The interdisciplinary approach of this proposed fellowship will refine a conceptual model that integrates genetic and prenatal environmental influences on child externalizing behaviors. The proposed fellowship will provide additional training to: (1) gain experience in environmental epidemiology, (2) gain experience in exposure mixture modeling, (3) develop an integrated conceptual model of the ways in which the prenatal environment moderates genetic and environmental influences on child social development, (4) strengthen networking, research dissemination, and grant writing skills, and (5) obtain additional training in the responsible conduct of research. This fellowship will augment my existing training in social contexts for child behavioral development with focused research and training in environmental epidemiology and behavioral genetics. Therefore, this work will support my career goal of becoming an independent researcher at the intersection of multiple fields crucial to the understanding of child behavioral development (developmental psychology, environmental epidemiology, and behavioral genetics).