Shared Resource: Biostatistics and Bioinformatics Facility

预防/信息共享资源：生物统计学和生物信息学 FACTORY（BBF） 项目总结/摘要 BBF在上次评论中被评为“优秀”。生物统计学和生物信息学设施（BBF）是一个共享的， 生物统计学和生物信息学合作以及相关方法研究机构资源。 BBF被公认为是研究基础设施的关键组成部分，并为癌症服务 来自所有五个研究项目的中心成员。BBF在Eric Ross博士和一名工作人员的指导下 为癌症中心成员提供严格的生物统计学和生物信息学设计、分析和 实验和研究的解释。设施工作人员在定量和计算方面具有广泛的技能， 用于临床试验、临床前研究、生物学实验、转化研究和癌症的方法 预防和控制问题。它的成员拥抱新的问题和技术， 快速变化的科学环境。机构生物统计学家在研究的所有阶段发挥重要作用 规划、报告和设计，包括样本量确定、随机化以及中期和最终 分析。生物信息学家为分析和探索各种实验室结果提供专业知识 包括高吞吐量数据。所有癌症中心的成员都可以随时访问BBF的协调和 具有成本效益的生物统计学和生物信息学服务。BBF维护统计和生物信息学软件 用于数据分析的软件包;可视化;样本量/功效估计;序列分析;途径和 网络分析和注释。BBF与实验室、癌症控制、翻译和临床的相互作用 研究人员已经扩展了对实验数据的解释，并对气候变化框架公约作出了重大贡献。 research. BBF成员从2011年到2015年6月发表了260篇论文（比2006年6月增加了91% 2010年）。BBF成员开发专门的生物统计学和生物信息学方法，以支持癌症 中心项目在临床试验设计、观察性研究方面产生了16篇方法学/第一作者出版物 方法和高通量数据分析。从2011年到2014年，BBF为该组织提供了39，359小时的支持， 105名癌症中心成员的研究活动。32，565小时用于支持同行评审资助的 来自五个研究项目。2014年，该设施提供了9，534个咨询小时，为90个 癌症中心成员。7，423小时用于支持67名同行评审成员。BBF评论了 所有涉及人类受试者的方案的统计学合理性与研究综述 以马克思它由设施咨询委员会（FAC）提供咨询，该委员会至少每年举行一次会议。 FAC的建议将提交给管理机构母公司监督委员会（FPOC）， 确保BBF继续拥有提供最高质量服务所需的资源， 为癌症中心成员提供定量服务。预计明年对服务的需求将增加 CCSG周期，由于计划在所有5个研究项目中招募，以及癌症中心的新需求 成员在TU。

COMPUTATIONAL/INFORMATICS SHARED RESOURCE: BIOSTATISTICS AND BIOINFORMATICS FACILITY (BBF) PROJECT SUMMARY/ABSTRACT BBF was rated "Outstanding" at the last review. The Biostatistics and Bioinformatics Facility (BBF) is a shared, institutional resource for biostatistics and bioinformatics collaboration and related methodological research. BBF is recognized Center-wide as a critical component of the research infrastructure and serves Cancer Center members from all five Research Programs. The BBF, with the direction of Eric Ross, PhD and a staff of 7 FTEs, provides Cancer Center members with rigorous biostatistics and bioinformatics design, analysis and interpretation of experiments and studies. Facility staff are broadly skilled in quantitative and computational methods for clinical trials, pre-clinical studies, biological experiments, translational investigations and cancer prevention and control problems. Its members embrace new problems and technologies that surface in a rapidly changing scientific environment. Facility biostatisticians play essential roles in all phases of study planning, reporting and design including sample size determination, randomization, and interim and final analyses. Bioinformaticians provide expertise for the analysis and exploration of diverse laboratory results including high throughput data. All Cancer Center members have ready access to the BBF’s coordinated and cost effective biostatistics and bioinformatics services. BBF maintains statistical and bioinformatics software packages for data analysis; visualization; sample size/power estimation; sequence analysis; pathway and network analysis; and annotation. BBF interactions with laboratory, cancer control, translational and clinical investigators have extended the interpretation of experimental data and contributed substantially to FCCC research. BBF’s members published 260 papers from 2011 to June 2015 (91% increase over 2006-June 2010). BBF members’ development of specialized biostatistics and bioinformatics methods to support Cancer Center projects resulted in 16 methodology/first author publications in clinical trial design, observational study methods and high throughput data analyses. From 2011-2014, BBF provided 39,359 hours of support to the research activities of 105 Cancer Center members. 32,565 hours were in support of peer-review-funded members from all five Research Programs. In 2014, the facility provided 9,534 consulting hours supporting 90 Cancer Center members. 7,423 hours were in support of 67 peer-reviewed members. BBF reviews the statistical soundness of all protocols involving human subjects in conjunction with the Research Review Committee. It is advised by a Facility Advisory Committee (FAC) that meets at least annually. Recommendations from the FAC are directed to a governing Facility Parent Oversight Committee (FPOC) that serves to ensure that the BBF continues to have the resources needed to provide the highest quality of quantitative services for Cancer Center members. Demand for services is expected to increase in the next CCSG cycle due to plans to recruit in all 5 Research Programs, and new demand from Cancer Center members at TU.