Informatics Core

项目概要-信息学核心 信息学核心（IC）的目标是促进和加强癌症中心内的精确癌症研究。 福克斯蔡斯癌症中心（FCCC）的预防拦截靶向药物发现计划（CAP-IT）， 为CAP-IT研究者提供专业的生物统计学、生物信息学和数据管理支持。成员 在应用于癌症的生物统计学和生物信息学方面具有丰富的知识和经验 预防研究，包括癌症风险评估，生物标志物分析和临床前化学预防。 这个高度互动的生物统计学家，生物信息学家和信息学家小组将提供以下专业知识： 符合严格科学、统计和生物信息学分析要求的实验设计， 和信息能力，以确保所有数据的高质量，存储在专业管理 数据库，并可与CAP-IT数据和资源协调中心（DRCC）共享。它将 服务于所有CAP-IT项目、管理核心，并支持未来的CAP-IT项目。 该中心的具体目标是：（1）提供实验和研究设计方面的专业知识，包括 研究方案的制定，样本量的确定，随机化程序，以及最终的计划 分析;（2）为CAP-IT研究人员进行统计和生物信息学分析，以评估经验证的 肿瘤靶点的作用性、药物性和/或癌症预防和/或拦截的可行性;（3）协助 与手稿的统计和生物信息学组成部分的写作和解释， （4）提供以计算机为基础的工具，以方便储存和检索所产生的数据 （5）与CAP-IT DRCC合作，建立一个集中的CAP-IT数据库， 网络内数据存档和共享;以及（6）对来自本地数据的分子数据进行生物信息学分析 来自高风险受试者的资源、公共数据库、细胞系和生物样本，以验证候选人 路径/目标。 为了实现这些目标，IC将利用来自NCI赞助的信息学计划的软件（例如， NCI癌症研究信息技术）和挖掘公开可用的数据资源，包括 癌症前图谱和NCI临床蛋白质组肿瘤分析联盟。通过提供量化技能和 数据管理和共享能力，信息中心将支持《气候变化框架公约》CAP-IT， 项目目标，促进新项目的设计和实施，并实现与CAP-IT的合作 通过DRCC网络。

PROJECT SUMMARY - INFORMATICS CORE The goal of the Informatics Core (IC) is to facilitate and enhance precision cancer research within the Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) at Fox Chase Cancer Center (FCCC) by providing expert biostatistics, bioinformatics, and data management support to CAP-IT investigators. Members of the Core have substantial knowledge and experience in biostatistics and bioinformatics as applied to cancer prevention research, including cancer risk assessment, biomarker analyses, and preclinical chemoprevention. This highly interactive group of biostatisticians, bioinformaticians and informaticians will provide expertise in experimental design that meets the requirements of rigorous science, statistical and bioinformatics analyses, and informatics capabilities to ensure that all data are of high quality, stored in professionally managed databases, and available for sharing with the CAP-IT Data and Resource Coordination Center (DRCC). It will serve all CAP-IT projects, the Administration Core, and support future CAP-IT projects. The specific goals of the IC are to: (1) Provide expertise in the design of experiments and studies, including research proposal development, sample size determination, randomization procedures, and plans for final analysis; (2) Perform statistical and bioinformatics analyses for CAP-IT investigators to assess validated oncotargets for actionability, druggability, and/or feasibility for cancer prevention and/or interception; (3) Assist with the writing of statistical and bioinformatics components of manuscripts and the interpretation and presentation of results; (4) Provide computer-based tools to facilitate the storage and retrieval of data generated in the proposed research; (5) Collaborate with the CAP-IT DRCC to populate a centralized CAP-IT database for in-network data archiving and sharing; and (6) Perform bioinformatics analyses of molecular data from local data resources, public databases, cell lines and biosamples from high-risk subjects to validate candidate pathways/targets. To accomplish these goals, the IC will leverage software from NCI-sponsored informatics initiatives (e.g., NCI Informatics Technology for Cancer Research) and mine publicly available data resources including the Precancer Atlas and the NCI Clinical Proteomic Tumor Analysis Consortium. By providing quantitative skills and data management and sharing capabilities, the IC will support the FCCC CAP-IT, facilitate achievement of project aims, contribute to the design and conduct of new projects, and enable collaborations with the CAP-IT Network though the DRCC.