CHAPS Cohort Maintenance

摘要 NIEHS/EPA共同赞助的儿童健康与空气污染研究(CHAPS) 环境健康中心，专注于空气污染对旧金山儿童成长的影响 加利福尼亚州的华金山谷，全国污染最严重的地区之一。CHAPS涉及招募 以及对两个特定年龄的儿童队列、一个在子宫内招募的婴儿队列和一个儿童队列的随访 6-8岁时被征召入伍。这两个队列的主要研究目标都是调查暴露于 环境空气污染，特别是多环芳烃(PAHs)和其他与交通有关的污染物； 关于免疫和新陈代谢失调。我们在两个队列中各招募了200多名儿童， 正在进行为期两年的跟踪调查。我们收集了以下生物标志物数据： 人体测量；血压(BP)；儿童队列中的肺活量测定；用于免疫的血液样本分析 调节、代谢功能和全身性炎症；以及尿液氧化应激检测。到目前为止， 我们的研究团队已经证实了一种新的表观遗传机制，环境中的多环芳烃和其他 污染物通过叉头盒P3基因的高甲基化导致儿童过敏性疾病 (Foxp3)，b)证实暴露在环境中的多环芳烃与儿童的肺功能下降有关， 以及c)表明，暴露于交通相关的空气污染物，包括环境中的多环芳烃，与BP有关， 血红蛋白A1c(HbA1c)、年龄体重指数和尿8-异前列腺素。我们在幼儿身上的发现是否会 随着儿童年龄的增长，预测未来的过敏性疾病和代谢综合征是一个重要的和当前的 悬而未决的问题。为了解决这个问题，我们在环境流行病学申请中提出了这个问题 欧洲经济共同体(EEC)为以下具体目标提供资金：1)保留并继续跟踪CHAPS婴儿和 未来5年的儿童队列；2)维护和加强数据管理基础设施；3) 维护和丰富CHAPS生物样品储存库；4)进行验证、试验和可行性 利用现有数据和样本进行研究；以及5)鼓励数据共享。性格鲜明的小伙子们 队列研究提供了研究交通相关空气污染对健康影响的机会 在一个以拉丁裔为主的低收入社区的青春期。拟议的欧共体将在#年提供证据 支持保护这类弱势社区健康的政策。

Abstract The Children’s Health and Air Pollution Study (CHAPS), one of the NIEHS/EPA co-sponsored Children’s Environmental Health Centers, has focused on the effects of air pollution on children growing up in the San Joaquin Valley of California, one of the most polluted areas in the country. CHAPS involves the recruitment and follow-up of two age-specific cohorts of children, an infant cohort recruited while in utero and a child cohort recruited at ages 6-8. The primary research goal for both cohorts is to investigate the effects of exposure to ambient air pollution, particularly polycyclic aromatic hydrocarbons (PAHs) and other traffic-related pollutants, on immune and metabolic dysregulation. We have recruited over 200 children in each of the two cohorts and are in the process of following them over a 2-year period. We have collected the following biomarker data: anthropometry; blood pressure (BP); spirometry in the child cohort; assays in blood samples for immune regulation, metabolic function, and systemic inflammation; and a urinary assay for oxidative stress. To date, our research team has a) confirmed a novel epigenetic mechanism by which ambient PAHs and other pollutants contribute to allergic disease in children through hypermethylation of the forkhead box P3 gene (FOXP3), b) confirmed that exposure to ambient PAHs is associated with reduced lung function in children, and c) shown that exposure to traffic-related air pollutants, including ambient PAHs, is associated with BP, hemoglobin A1c (HbA1c), BMI-for-age, and urinary 8-isoprostane. Whether our findings in young children will predict future allergic disease and metabolic syndrome as the children age is an important and currently unanswered question. To address this question we propose in our application for Environmental Epidemiology Cohort (EEC) funding the following specific aims: 1) to retain and continue to follow both CHAPS infant and child cohorts over the next 5 years; 2) to maintain and strengthen data management infrastructure; 3) to maintain and enrich the CHAPS repository of biospecimens; 4) to conduct validation, pilot, and feasibility studies using existing data and samples; and 5) to encourage data sharing. The well-characterized CHAPS cohorts provide the opportunity to study the health effects of traffic-related air pollution from birth through adolescence in a low-income, predominantly Latinx community. The proposed EEC will provide evidence in support of policies to protect the health of such vulnerable communities.