Lineage heterogeneity and plasticity in lung cancer

项目摘要 这是一个研究补充，以促进健康相关研究的多样性（PA-20-222）的应用程序。 与本申请相关的父R 01项目的标题为“肺的谱系异质性和可塑性 癌症”由NCI支持（5 R 01 CA 240342 - 02）。道格拉斯曼塞尔是多元化的候选人。他是美国公民 非裔美国人后裔，目前是西奈山伊坎医学院的博士后研究员， 纽约。本研究的主要目标是描述我们的主要候选者之一PBX 1的重要性 定义了肺腺癌的一个新亚型的谱系状态。我们将测试特定于子类的本地 染色质结构，然后研究新的谱系转录因子的作用，特别是丰富的染色质结构， 肺腺癌的亚组，它们是否对维持肺癌的细胞状态至关重要 细胞，并依赖于其生存的承诺谱系。

PROJECT SUMMARY This is an application for a Research Supplement to Promote Diversity in Health-Related Research (PA-20-222). The parent R01 project associated with this application is entitled “Lineage Heterogeneity and Plasticity in Lung Cancer” supported by NCI (5R01CA240342 -02). Douglas Mansell is the diversity candidate. He is a US citizen of African-American descent and is currently a postdoctoral fellow at Icahn School of Medicine at Mount Sinai, New York. The main goal of this study is to characterize the significance of one of our lead candidates PBX1 defining the lineage state of a novel subset of lung adenocarcinoma. We will test the subclass-specific local chromatin structure and then investigate the roles of novel lineage transcription factors specifically enriched in the subgroup of lung adenocarcinoma, whether they are essential for maintaining the cellular state of lung cancer cells and are dependent on the committed lineage for their survival.