同位素标记快速抗菌药物敏感性测试-猫眼课题宝

同位素标记快速抗菌药物敏感性测试

批准号：

10325820

负责人：

ERIK J NILSSON

金额：

$25.65万

依托单位：

PATAIGIN, LLC

依托单位国家：

美国

项目类别：

财政年份：

2021

资助国家：

美国

项目状态：

已结题

起止时间：

2021-07-01 至 2023-01-31

来源：

https://reporter.nih.gov/project-details/10325820

关键词：

Adopted Agreement Antibiotic Therapy Antibiotics Antimicrobial Resistance Antimicrobial susceptibility Bacteremia Bacteria Baltimore Biological Assay Biological Markers Biotechnology Cell Culture Techniques Cessation of life Characteristics Clinical Collaborations Communicable Diseases Companions Culture Media Death Rate Deuterium Deuterium Oxide Development Diagnosis Diagnostic Reagent Kits Equipment Experimental Designs FDA approved Goals Gold Growth Health Hospitals Hour Incidence Incubated Infection Intervention Isotope Labeling Laboratories Life Lipids MALDI-TOF Mass Spectrometry Maryland Medical Medical Device Medical center Microbiology Minimum Inhibitory Concentration measurement Morbidity - disease rate Patients Performance Phospholipids Predisposition Preparation Privatization Process Public Health Reagent Reporting Reproducibility Research Research Personnel Research Proposals Resistance Running Sampling Sepsis Septicemia Specimen Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Speed Techniques Testing Time Universities Work antimicrobial base cost cost effective detection limit fighting innovation instrument mass spectrometer medical schools method development microbial mortality novel pathogen resistance mechanism tool

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中文摘要

翻译

摘要本建议是一种快速的抗菌药物敏感性试验。菌血症和脓毒症仍然是主要的健康问题，死亡率高。进展往往很快，因此，每节省1小时的诊断时间就能显著降低败血症死亡率。需要更快的测试，拯救生命我们提出了Rigel，一种快速的抗菌药物敏感性测试，利用一种新的同位素标记机制

英文摘要

Abstract This proposal is for a rapid antimicrobial susceptibility test. Bacteremia and sepsis remain major health problems with high mortality. Progression is often rapid, so that a single hour saved in diagnosis time can significantly reduce septicemia death rates. Faster tests are needed to save lives. We propose Rigel, a rapid antimicrobial susceptibility test that makes use of a novel isotopic labelling mechanism.

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