Small-molecule therapy for metastatic castration-resistant prostate cancer

转移性、耐去势前列腺癌(MCRPC)是致命的，无法治愈。尽管目前的治疗方法 最初延长生存，患者通常会复发并产生治疗耐药性，这是一个主要的 前列腺癌治疗中的障碍。开发治疗致命疾病的有效疗法势在必行 MCRPC，提高患者的生存率。在第一阶段STTR期间，我们发现了一种新的小- S时相激酶相关蛋白1-F盒蛋白相互作用的分子抑制物，即 GH501，显示出对mCRPC和广泛的人类癌细胞系的纳摩尔效力。 我们已经对GH501的临床前安全性、药代动力学、分布和疗效进行了初步研究 针对mCRPC。在这个第二阶段的STTR项目中，我们将测试我们的先导化合物的中心假设 GH501是一种一流的Skp1-FBP抑制剂，能有效治疗mCRPC。建议的研究是建立的 关于：(1)迫切和未得到满足的医疗需要，以开发新的致命mCRPC干预措施，(2)当务之急 需要确定mCRPC的新治疗靶点；以及(3)强有力的临床前证据支持GH501作为一种 新型高效的mCRPC抑制剂。总体目标是进行新药研究- 使GH501作为治疗致死性mCRPC的候选药物的毒理学和疗效研究成为可能。在……里面 目的1，我们将开发一种GH501的口服制剂，并验证GH501具有极好的安全性的假设 以及临床前模型中的类药物特性。在目标2中，我们将验证GH501和 验证作为一种新的Skp1抑制剂，GH501在临床上对mCRPC有效的假设 异种移植模型。完成拟议的项目和后续的临床前研究将使我们能够准备 在未来3~4年内应用IND将GH501推进到人体试验中。这种高度创新的， 翻译项目可能会在降低前列腺癌死亡率和发病率方面产生重大影响。

Metastatic, castration-resistant prostate cancer (mCRPC) is lethal with no cure. Although current treatments initially prolong survival, patients generally relapse and develop therapeutic resistance, which is a major obstacle in the management of prostate cancer. It is imperative to develop efficacious therapies to treat lethal mCRPC and improve the survivorship of patients. During the Phase I STTR period, we identified a novel small- molecule inhibitor of S phase kinase-associated protein 1 (Skp1) – F-Box protein (FBP) interaction, namely GH501, that exhibits nanomolar potency against mCRPC and a broad spectrum of human cancer cell lines. We have conducted pilot studies on the preclinical safety, pharmacokinetics, distribution and efficacy of GH501 against mCRPC. In this Phase II STTR project, we will test the central hypothesis that our lead compound GH501 is a first-in-class Skp1-FBP inhibitor that effectively treats mCRPC. The proposed studies are built upon: (1) an urgent and unmet medical need to develop new interventions for lethal mCRPC, (2) an imperative need to identify new therapeutic targets in mCRPC; and (3) strong preclinical evidence supporting GH501 as a novel and effective inhibitor of mCRPC. The overall objective is to conduct Investigational New Drug (IND)- enabling toxicology and efficacy studies on GH501 as a drug candidate for the treatment of lethal mCRPC. In Aim 1, we will develop an oral formulation of GH501 and test the hypothesis that GH501 has excellent safety and drug-like properties in preclinical models. In Aim 2, we will validate the mechanism of action of GH501 and test the hypothesis that as a novel Skp1 inhibitor, GH501 is efficacious against mCRPC in clinically-relevant xenograft models. Completion of the proposed project and follow-up preclinical studies will allow us to prepare an IND application within the next 3~4 years to advance GH501 into human trials. This highly innovative, translational project could have a significant impact in reducing prostate cancer mortality and morbidity.