National Cancer Institute (NCI) Cancer Clinical Investigator Team Leadership Award (CCITLA) P30 Administrative Supplement for Fiscal Year (FY) 2021

范德比尔特-英格拉姆癌症中心总体 项目总结/摘要 这是范德比尔特-英格拉姆癌症中心癌症中心支持补助金（CCSG）的第五次竞争性更新 中心（维也纳国际中心）。VICC是范德比尔特大学医学中心和范德比尔特大学的矩阵中心 它整合了医学院、护理学院、艺术学院和 科学与工程学院、皮博迪教育学院和完全一体化的退伍军人管理局 医学中心主要的临床设施和大多数研究设施都位于一个校区， 促进非正式互动、资源共享和富有成效的合作。成立于1993年， 维也纳国际中心是一个具有超部门地位的组织单位。维也纳国际中心的具体责任和 目标是：1）开展、支持和加强最先进的多学科基础、临床和人口- 2）协调和整合范德比尔特的癌症相关活动，并与 我们的地方，区域，国家和全球合作伙伴; 3）培训和开发下一代癌症 研究人员，癌症领导人和癌症护理提供者的连续体;和4）评估和优先考虑 社区的需要，并利用伙伴关系，通过癌症研究，护理和 控制活动。研究、培训和社区外展和参与目标得以实现 通过CCSG和机构支持的组织能力、规划和评估， 研究项目。VICC的研究项目是信号转导和细胞增殖，基因组 维持，宿主-肿瘤相互作用，胃肠道癌，转化研究和介入 肿瘤学、乳腺癌、癌症流行病学和癌症健康结果与控制。11分享 拟议资源以前都得到支持。VICC的显著增长和科学发现， 在过去的项目期间，共为71名研究人员提供了22项新的多研究人员赠款，为一名研究人员提供了8项新的培训赠款。 共26个。此外，两个NCI SPORE成功续约。有了这些和许多其他NCI赠款， 同行评审的资金增加了35%。在精准肿瘤学方面取得了重大成就， 癌症流行病学，健康结果和控制，基因组学，癌症药物发现，早期发现和 预防和癌症差异研究。增加维也纳国际中心的空间和设施，沿着慈善和 机构资金，支持招聘67名新教师，他们加入了一个专门的团队，执行VICC 使命：通过开拓性研究、创新的以病人为中心的护理，减轻癌症死亡和痛苦; 以及循证预防、教育和社区举措。维也纳国际中心高级领导层提供有效的 监督和催化创新和范式转变的科学，转化为造福我们的病人， 我们在我们的流域服务的社区，并减少国家和全球的癌症负担。

VANDERBILT-INGRAM CANCER CENTER OVERALL PROJECT SUMMARY/ABSTRACT This is the fifth competing renewal of the Cancer Center Support Grant (CCSG) at Vanderbilt-Ingram Cancer Center (VICC). VICC is a matrix center within Vanderbilt University Medical Center and Vanderbilt University that integrates the cancer-related expertise and resources of the Schools of Medicine, Nursing, Arts and Sciences and Engineering, the Peabody School of Education and the fully integrated Veterans Administration Medical Center. The major clinical facilities and the majority of research facilities are located on one campus, which promotes informal interactions, sharing of resources and productive collaborations. Established in 1993, VICC functions as an organizational unit with a supra-departmental status. VICC-specific responsibilities and aims are 1) to conduct, support and enhance state-of-the-art, multidisciplinary basic, clinical and population- based research; 2) to coordinate and integrate cancer-related activities across Vanderbilt and to collaborate with our local, regional, national and global partners; 3) to train and develop the next generation of cancer investigators, cancer leaders and the continuum of cancer care providers; and 4) to assess and prioritize community needs and to leverage partnerships to address those needs through cancer research, care and control activities. The research, training, and community outreach and engagement objectives are accomplished through CCSG and institutionally supported organizational capabilities, planning and evaluation, and eight research programs. The VICC Research Programs are Signal Transduction and Cell Proliferation, Genome Maintenance, Host-Tumor Interactions, Gastrointestinal Cancer, Translational Research and Interventional Oncology, Breast Cancer, Cancer Epidemiology, and Cancer Health Outcomes and Control. Eleven shared resources are proposed, all previously supported. Remarkable VICC growth and scientific discovery over the past project period has led to 22 new multi-investigator grants for a total of 71, and 8 new training grants for a total of 26. In addition, two NCI SPOREs were successfully renewed. With these and many other NCI grants, peer-reviewed funding increased 35%. Significant accomplishments have been made in precision oncology, cancer epidemiology, health outcomes and control, genomics, cancer drug discovery, early detection and prevention, and cancer disparities research. Increased VICC space and facilities, along with philanthropic and institutional funds, supported the recruitment of 67 new faculty, who join a dedicated team carrying out the VICC mission: to alleviate cancer death and suffering through pioneering research; innovative patient-centered care; and evidence-based prevention, education and community initiatives. VICC senior leadership provides effective oversight and catalyzes innovative and paradigm-shifting science that translates to benefit for our patients and the community we serve in our catchment and reduces the burden of cancer nationally and globally.