Sleep health in special populations

项目摘要 睡眠障碍导致的睡眠不足和质量差会对健康产生负面影响 结果和生活质量。对于有不良结局风险的患者人群尤其如此 因为合并症虽然有既定的治疗和最佳实践管理睡眠 包括睡眠呼吸暂停和失眠在内的疾病，在如何最好地管理 复杂的患者，并改善以患者为中心的结果。此应用程序的目标是提供支持， 在患者的睡眠障碍和睡眠健康方面指导受训人员和初级研究人员 “处于危险之中”的人。申请人目前的研究计划主要集中在妇女与睡眠 呼吸暂停，与男性相比，他们不依从PAP治疗的风险较高，特别是当他们 在依从性方面面临额外的挑战，例如精神病合并症。主要研究目标 资助的工作重点是提高妇女对PAP疗法的坚持。其他目标侧重于改善 脊髓损伤患者的PAP依从性和实施改善睡眠的实践 长期护理设施。马丁博士有指导学员在多个层次的研究记录 独立性，拟议的奖项将提高她的能力，提供额外的指导，在病人 研究重点是睡眠障碍和睡眠健康。该奖项的目标是增加 一些独立的临床研究人员研究如何最好地治疗“真实的睡眠障碍患者” 世界”设置。因此，拟议培训计划的目标侧重于为Martin博士提供以下方面的培训： 执行科学。加州大学洛杉矶分校和弗吉尼亚州大洛杉矶医疗保健系统（VAGLAHS）提供丰富的 指导和应用临床和卫生服务研究的环境。最后，WEB的开发 将为面向患者的研究中的临床实习生开发基于资源，供内部和外部使用 加州大学洛杉矶分校和流浪汉。

PROJECT SUMMARY Insufficient and poor quality sleep resulting from sleep disorders can have a negative impact on health outcomes and quality of life. This is particularly true for patient populations who are at risk for poor outcomes due to comorbidities. While there are established treatments and best practices for management of sleep disorders, including sleep apnea and insomnia, significant knowledge gaps remain in how best to manage complex patients and improve patient-centered outcomes. The goal of this application is to provide support for mentoring of trainees and junior investigators in the areas of sleep disorders and sleep health among patient populations who are “at risk.” The applicant's current research program focuses primarily on women with sleep apnea, who are at elevated risk for non-adherence to PAP therapy compared to men, particularly when they face additional challenges to adherence, such as psychiatric comorbidities. The main research aims of the funded work focus on improving adherence to PAP therapy among women. Additional aims focus on improving PAP adherence among patients with spinal cord injuries and on implementing practices to improve sleep in long term care settings. Dr. Martin has a track record of mentoring trainees at multiple levels toward research independence, and the proposed award will enhance her ability to provide additional mentoring in patient oriented research focused on sleep disorders and sleep health. The goal of the award is to increase the number of independent clinical investigators studying how best to treat patients with sleep disorders in “real world” settings. As such, the goals of the proposed training plan focus on providing Dr. Martin with training in implementation science. UCLA and the VA Greater Los Angeles Healthcare System (VAGLAHS) provide rich environments for mentoring and for applied clinical and health services research. Finally, development of web- based resources for clinical trainees in patient oriented research will be developed for use within and beyond UCLA and VAGLAHS.