Human Immune Monitoring Center

项目总结/摘要 Tisch癌症研究所（TCI）人类免疫监测核心共享资源设施（HIMCSRF） 为TCI成员提供了一套全面的免疫监测检测， 循环蛋白质的定量和免疫细胞表征，沿着空间组织， 组织，以支持基础科学，临床和转化研究。这是通过平衡创新来实现的 通过强大的协议和操作程序，以确保数据质量和再现性， 用于生物样本处理和样本管理、可溶性因子分析、表型和 功能性免疫细胞表征、免疫基因组学、单细胞转录组学和多路复用 组织成像HIMCSRF由20多名全职专家组成，他们专门研究 免疫概况和反应在各种疾病的设置。HIMC目前支持超过 45个联邦和基金会资助的项目，涉及包括癌症在内的各种临床领域， 作为几个多机构联盟的中心分析中心，包括NIH人类免疫学 项目财团。HIMCSRF也是NCI指定的癌症免疫监测和分析 中心（CIMAC）作为通过癌症登月计划资助的U24财团的一部分， 支持13个行业赞助的研究合作。自2011年成立以来，HIMCSRF 为TCI的使命提供最先进的技术，项目开发，一致性， 所有TCI计划的解释和成本效益。

PROJECT SUMMARY/ABSTRACT The Tisch Cancer Institute (TCI) Human Immune Monitoring Core Shared Resource Facility (HIMCSRF) provides TCI members access to a comprehensive suite of immune monitoring assays allowing for the quantification of circulating proteins and immune cell characterization, along with spatial organization in tissues to support basic science, clinical, and translational studies. This is achieved by balancing innovation with robust protocols and operating procedures to ensure data quality and reproducibility with dedicated platforms for biospecimen processing and sample management, soluble factor profiling, phenotypic and functional immune cell characterization, immunogenomics, single cell transcriptomics, and multiplexed tissue imaging. The HIMCSRF is comprised of over twenty full time experts who specialize in characterizing immune profiles and responses across a diverse range of disease settings. The HIMC currently supports over 45 federal and foundation funded projects across a diverse range of clinical areas including cancer, and also serves as a central analysis hub for several multi-institutional consortia including the NIH Human Immunology Project Consortium (HIPC). The HIMCSRF is also an NCI-designated Cancer Immune Monitoring and Analysis Center (CIMAC) as part of a U24 consortium funded through the Cancer Moonshot program, and also actively supports 13 industry-sponsored research collaborations. Since its inception in 2011, the HIMCSRF contributed to the TCI’s mission by providing state-of-the-art technologies, project development, consistency, interpretations, and cost-effectiveness to all TCI programs.