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中文摘要
翻译
项目概要(项目2) 基于WashU-UCSC-EBI的人类基因组参考中心(HGRC)的目标是维护和更新 由人类基因组参考计划(HGRP)生产的新人类基因组参考,并提供 向科学界。HGRP外联和教育中心(HGRP-OE)的目标是 与整个科学和医学界沟通,传播数据、资源、工具, 协议和教育材料。为了支持HGRC和整个HGRP联盟,我们将提供 向社区提供有关基因组参考的信息,从社区获得反馈,并作出回应 社区需求。为了实现这一目标,我们提出了创新和强大的战略,定义如何HGRP 将与更广泛的用户社区互动。我们将开发一个HGRP门户网站, 新的人类基因组参考的接口和相关数据和工具的资源库。这 新资源将与目前支持生物医学研究的许多其他基因组资源紧密相连。 我们将制定全面的策略来培训用户并更新参考文献的当前状态, 包括一个全面的教育网站、一套基于网络的培训模块、研讨会和网络研讨会, 会议研讨会以及区域、巡回研讨会,用于移动的设备的HGRP APP,以及 通过社交媒体进行宣传。重要的是,我们将从当前的参考程序集制定过渡计划 (GRCh 37和GRCh 38)到新的人类泛基因组参考,并严格从事研究人员和 更广泛的社区,以协助过渡。我们提出计划,主动连接用户反馈和响应 如果成功实施,我们提出的HGRP-OE将大大提高社区对 新的人类基因组参考及其使用,从而最大限度地发挥其使用,价值和意义。
英文摘要
PROJECT SUMMARY (PROJECT 2) The goal of the WashU-UCSC-EBI based Human Genome Reference Center (HGRC) is to maintain and update the new human genome reference produced by the Human Genome Reference Program (HGRP) and to provide it to the scientific community. The goal of the HGRP Outreach and Education Center (HGRP-OE) is to communication with the entire scientific and medical communities and disseminate data, resources, tools, protocols, and educational materials. To support the HGRC and the entire HGRP consortium, we will provide information to the community about the genome reference, obtain feedback from the community, and respond to community needs. Towards this goal, we propose innovative and robust strategies that define how the HGRP will engage with the broader user community. We will develop an HGRP web portal that serves as a user interface for the new human genome reference and a resource repository for the associated data and tools. This new resource will be tightly linked with many other genomic resources currently supporting biomedical research. We will develop comprehensive strategies to train and update users on the current state of the reference, including a comprehensive educational website, a suite of web-based training modules, seminars and webinars, workshops at conferences as well as regional, traveling workshops, an HGRP APP for mobile devices, and outreach via social media. Importantly, we will develop a transition plan from the current reference assemblies (GRCh37 and GRCh38) to the new human pan-genome reference, and rigorously engage investigators and the broader community to assist the transition. We present plans to proactively connect user feedback and respond to it. If successfully implemented, our proposed HGRP-OE will greatly increase community awareness of the new human genome reference and its usage, and thus maximize its use, value, and significance.
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Endogenous retrovirus in joint aging and osteoarthritis development
  • 批准号:
    10719364
  • 项目类别:
  • 资助金额:
    $60.78万
  • 财政年份:
    2023
  • 负责人:
    Ting Wang
  • 依托单位:
2023 Cancer Genetics and Epigenetics GRC & GRS
  • 批准号:
    10683603
  • 项目类别:
  • 资助金额:
    $1.6万
  • 财政年份:
    2023
  • 负责人:
    Ting Wang
  • 依托单位:
WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center
  • 批准号:
    10474397
  • 项目类别:
  • 资助金额:
    $249.32万
  • 财政年份:
    2021
  • 负责人:
    Ting Wang
  • 依托单位:
WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center
  • 批准号:
    10631116
  • 项目类别:
  • 资助金额:
    $157.76万
  • 财政年份:
    2021
  • 负责人:
    Ting Wang
  • 依托单位:
国内基金
海外基金
层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
  • 批准号:
    2021JJ40433
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2021
  • 负责人:
    孙磊
  • 依托单位:
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
  • 批准号:
    32001603
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    24.0万元
  • 批准年份:
    2020
  • 负责人:
    段真珍
  • 依托单位:
AREA国际经济模型的移植.改进和应用
  • 批准号:
    18870435
  • 项目类别:
    面上项目
  • 资助金额:
    2.0万元
  • 批准年份:
    1988
  • 负责人:
    史树中
  • 依托单位: