Data Management and Statistical Core

项目摘要：数据管理和统计核心！ 数据管理和统计核心(DMSc)是为了支持俄勒冈州的总体目标而调整的 ADRC的两个首要目标：(1)侧重于及早发现变化，以便确定机制 支持健康的大脑老化和向MCI和早期痴呆的过渡，以及(2)促进发育 预防或调解这些转变的有效疗法。 促进针对症状前期到早期MCI谱的研究，痴呆症的危险因素 作为最古老和最新的治疗方法，OADC的DMSc支持一系列不同的研究 从纵向生物标志物数据的统计建模到通过自动化的实时变化检测 家庭活动传感器评估。这些活动促进了美洲反兴奋剂机构的研究目标， 症状前期到早期轻度认知障碍(MCI)领域的创新与发现 在最古老的治疗方法和新的治疗方法中，痴呆症的危险因素。这项研究是最好的 作为团队科学在多个单位、中心和部门进行，包括生物医学 工程学和医学信息学系。在这一非凡的协作和互动中 环境中，比以往任何时候都更需要OADRC DMSc来确保来自 多个来源并提供及时分发的定制数据文件以及深思熟虑的统计 并为广泛的研究人员提供适当的分析和咨询。在这一背景下和在 作为对RFA的回应，DMSc的具体目标是： 1.开发和维护功能性纵向研究数据库，并共享数据 2.与国家阿尔茨海默氏症协调中心(NACC)及相关中心合作 3.提供生物统计分析和咨询 4.为早期调查人员提供丰富的统计知识环境， 受训人员和OADC附属公司。

Project Summary: Data Management and Statistical Core! The Data Management and Statistical Core (DMSC) is aligned to support the overall goal of the Oregon ADRC’s two overarching aims: (1) to focus on early detection of change in order to define mechanisms supporting healthy brain aging and the transition to MCI and early dementia, and (2) to facilitate developing effective therapies to prevent or mediate these transitions. Fostering research directed toward the pre-symptomatic to early MCI spectrum, risk factors of dementia among the oldest old and novel treatments, the OADC’s DMSC supports an array of distinct investigations ranging from statistical modeling of longitudinal biomarker data to real-time change detection through automated in- home activity sensor assessments. These activities advance OADRC research goals directed toward innovation and discovery in the areas of the pre-symptomatic to early Mild Cognitive Impairment (MCI) spectrum, risk factors of dementia among the oldest old and novel treatments. This research is optimally conducted as team science across multiple units, centers and departments including the biomedical engineering and medical informatics departments. In this exceptionally collaborative and interactive environment, the OADRC DMSC is required more than ever to ensure the integrity of the data coming from multiple sources and to provide prompt distribution of customized data files as well as statistically thoughtful and appropriate analyses and consultations for a wide range of researchers. Within this context and in response to the RFA, the DMSC’s Specific Aims are to: 1. Develop and maintain a functional longitudinal research database and share the data 2. Collaborate with the National Alzheimer’s Coordinating Center (NACC) and related centers 3. Provide biostatistical analyses and consultation 4. Provide an enriched environment that increases statistical knowledge for early-stage investigators, trainees and OADC affiliates.