Administrative Core

项目摘要：管理核心 行政核心是为了支持OADRC的5个总体目标的总体具体目标：1) 促进和支持AD和相关痴呆(ADRD)方面的创新研究和发现 支持丰富协作环境的组织基础设施；2)将资源集中到特定的 重点领域：临床前痴呆和疾病活动性，重点是年龄最大的老年人； 通过研究外周生物标志物、神经成像和在家中持续进行，捕捉到有意义的变化 行为监测；脑老化和老年痴呆的神经病理学；新治疗方法的新测试； 并改善有关痴呆症的教育和知识；3)通过以下方式提供材料支持科学 充分描述研究参与者、生物标本、脑组织、数据提供和分析；4) 促进与阿尔茨海默病和相关疾病相关的国家研究共享空间；以及5)提供场所和 建立教育和培训新科学家的机制，并对主要利益攸关方进行教育和告知。 OADRC的行政核心为以下活动提供监督、管理和质量保证 中心。它在加强和改进科学和技术之间的现有联系方面发挥牵头单位的作用 地方和国家的适当的非专业社区领袖和组织。它负责促进 无论何时何地，与大脑老化和痴呆症相关的新的和创新的研究。这个 行政核心具体目标是： 1.协调和整合对外援助和发展中心的各个核心单位和资源及其与 相互之间，以及与个别科学家、临床医生、教育工作者和社区的合作。 2.监督和监督中心的方向和互动，设定相关目标和优化 资源利用，由科学界和非科学界的投入指导。 3.对进展情况进行持续的、定期的审查。确保OADRC内的每个单位都达到以下标准 最高的质量和生产力，同时严格遵守人类主体、动物福利、 科学诚信，以及大学和国立卫生研究院的财务政策要求。 4.提供一个架构和论坛，以培育和发展在脑老化和脑老化方面的创新研究 痴呆症，包括OADRC发展项目。 5.促进与其他阿尔茨海默病患者的协作研究、科学互动和数据共享传输 疾病研究中心，国家阿尔茨海默病协调中心，阿尔茨海默病 合作研究单位，阿尔茨海默氏症临床试验联合会，国家中央资料库 阿尔茨海默氏症和其他相关的外部研究小组。

Project Summary: Administrative Core The Administrative Core is aligned to support the overall specific aims of the OADRC's 5 overarching aims: 1) catalyze and sustain innovative research and discovery in AD and related dementias (ADRD) through an organizational infrastructure supporting a rich collaborative environment; 2) focus resources toward specific areas of emphasis: preclinical dementia and activity of disease emphasizing the oldest old; markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; neuropathology of brain aging and late life dementia; novel testing of novel treatments; and improving education and knowledge about dementia; 3) provide materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics; 4) contribute to the national research commons relevant to AD and related disorders; and 5) provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders. The OADRC’s Administrative Core provides oversight, management and quality assurance for the activities of the Center. It acts as the lead unit in strengthening and improving existing links between scientific and appropriate lay community leaders and organizations both locally and nationally. It is responsible for fostering new and innovative research relevant to brain aging and the dementias wherever and whenever possible. The Administrative Core Specific Aims are to: 1. Coordinate and integrate the individual core units and resources of the OADRC and their interactions with each other, as well as with individual scientists, clinicians, educators and the community. 2. Oversee and monitor the directions and interactions of the Center, setting relevant goals and optimizing resource utilization, guided by input from the scientific and lay communities. 3. Perform ongoing, regular review of progress. Ensure each unit within the OADRC performs to standards of highest quality and productivity while operating in strict compliance with human subjects, animal welfare, scientific integrity, and financial policy requirements of the university and NIH. 4. Provide a structure and forum to foster and develop new and innovative research in brain aging and the dementias, including the OADRC Developmental Projects. 5. Facilitate collaborative research, scientific interactions, and data sharing transfer with other Alzheimer’s Disease Research Centers, the National Alzheimer’s Coordinating Center, the Alzheimer’s Disease Cooperative Study Unit, the Alzheimer’s Clinical Trials Consortium, the National Centralized Repository for Alzheimer’s Disease and other relevant outside research groups.