One Health; Epidemiology of natural and deliberate contaminants (infectious and toxicities) in animals and animal food

项目摘要 在美国，供宠物食用的食物通常对宠物和人类都是安全的 拿着食物。抗菌素耐药性(AMR)及其传播是至关重要的问题。理解的提高 AMR的检测及其传播是一个至关重要的问题。准备对新旧病原体做出反应的能力是 派拉蒙。从目前的大流行中可以清楚地看到，SARS-CoV-2已经导致数百万人患病和死亡 全世界。它也有生病的宠物，许多物种被动物园收藏，似乎找到了一种 鹿体内的蓄水池。这个问题的严重程度仍然没有得到充分的认识。 佐治亚大学(UGA)致力于促进、培训和开展以下各个领域的研究 动物、人类和环境健康。兽医学院和国家兽医学院 诊断实验室(AVDL)有责任对国家及其组成部分进行诊断、监测趋势和 报告不寻常的疾病表现或模式。AVDL实验室是由我所获得的 2020年获得CLIA认证，并于同年8月开始进行人类COVID19聚合酶链式反应检测，以帮助 UGA社区继续其教学、研究和服务使命。此外，PI还实现了 2021年1月进行唾液检测，以提高样本采集和监测参与度。我们已经处理了 超过8万个人体样本，检测今天仍在继续。我们对兽医社区的服务并没有 在这段时间里摇摆不定。除了常规的兽医诊断服务外，分子部门还检测了 并发现宠物和动物园物种感染了SARS-CoV-2病毒。 我们的实验室在病理学、细菌学、寄生虫学、病毒学、血清学和分子生物学方面拥有专业知识， 包括高吞吐量平台测试，如COVID19测试所示。我们的教职员工 非常合格，致力于动物和公共卫生。我们的承诺体现在我们参与 许多州和国家层面的项目。我们是国家动物卫生实验室网络的一员 (NAHLN)，并参与所有NAHLN监测和抗菌素耐药性测试和测序。在……里面 此外，我们还参与了与FDA的其他合作协议，以评估 以火鸡为基础的宠物食品中的沙门氏菌，并进行了一项流行病学研究，以期了解 猫狗粪便中沙门氏菌及携带沙门氏菌的潜在危险因素我们也是FDA 细菌分离源实验室为他们的抗菌素持续耐药性测试项目。 此外，我们目前正处于基础设施拨款第二次竞争性续期的最后一年， 在此，我们正在寻求更新。我们对这笔拨款的所有要求都作出了非常积极的回应 约会。因此，雅典兽医诊断实验室和PI在这方面的应用是独一无二的 帮助FDA实现本竞争文件中描述的项目的关键目标 更新。

Project Summary In the United States, food destined for pet consumption usually is safe for both the pets and the people who handle the food. Antimicrobial resistance (AMR) and its spread are crucial issues. Understanding improving AMR detection and its spread is an essential issue. The ability to be ready to respond to old new pathogens is paramount. It is clear from the current pandemic, where SARS-CoV-2 has sicked and killed millions of people worldwide. It also has sickened pets, many species held in zoo collections, and seems to have found a reservoir in deer. The extent of the problem is still not fully recognized. The University of Georgia (UGA) is committed to promoting, training, and conducting research in all areas of animal, human and environmental health. The College of Veterinary Medicine and the State Veterinary Diagnostic Laboratory (AVDL) have a duty to the state and its constituents to diagnose, monitor trends, and report unusual disease presentations or patterns. The AVDL laboratory is supported by our institution obtained CLIA accreditation in 2020 and started performing human COVID19 PCR testing in August of that year to help the UGA community continue its teaching, research, and service missions. Moreover, the PI implemented saliva testing in January 2021 to improve sample collection and surveillance participation. We have processed over 80,000 human samples, and testing continues today. Our service to the veterinary community did not waver during this time. In addition to the regular veterinary diagnostic service, the molecular section also tested and found pets and zoo species sickened by SARS-CoV-2. Our laboratory has expertise in pathology, bacteriology, parasitology, virology, serology, and molecular biology, including high throughput platform testing as demonstrated with COVID19 testing. Our faculty and staff are highly qualified and are devoted to animal and public health. Our commitment is evident in our participation in many programs at the state and national levels. We are one of the National Animal Health Laboratory Network (NAHLN) and participate in all NAHLN surveillance and antimicrobial resistance testing and sequencing. In addition, we have participated in other cooperative agreements with the FDA assessing the presence of Salmonella in turkey-based pet treats and engaging in an epidemiological study looking at the prevalence of Salmonella in dog and cat feces and the potential risk factors for Salmonella carriage. We are also an FDA bacterial isolate source laboratory for their antimicrobial continued resistance testing project. Furthermore, we are currently in the last year of our second competitive renewal of this infrastructure grant, for which hereby we are seeking renewal. We have been very responsive to all the requirements of this grant to date. Therefore, Athens Veterinary Diagnostic Laboratory and the PI in this application are uniquely positioned to assist the FDA in meeting the critical goals of the project described in this competitive renewal.