SWOG Statistics and Data Management Center

项目摘要/摘要 整体组件 SWOG统计和数据管理中心(SDMC)在统计设计、数据 NCTN临床试验的管理、分析和报告。它为SWOG的总体使命做出了贡献 通过癌症临床试验和转化性研究显著改善生活。 SDMC的目标是：(A)快速设计、开发和实施严谨高效的多中心 临床试验；(B)加强对正在进行的试验进行最佳监测的系统，并确保研究的可重复性 使用交叉研究标准化软件和系统进行统计分析和临床试验报告；(C) 开发创新的统计设计和软件工具，将综合和综合生物标记物纳入 临床试验；(D)与其他研究人员合作进行统计方法研究，包括临床试验设计 以及转化医学研究的分析，重点是精准医学和 评价免疫疗法；(E)研究通过建立联系加强非传染性疾病数据的新战略 到外部数据库，建立SWOG临床和转化医学综合信息库 数据；和(F)推动国家癌症研究所方案和国家癌症研究所研究议程的科学性，#年 与NCTN其他调查人员结成伙伴关系，通过参与活动提供科学领导 例如指导委员会、工作组、工作组、数据共享和临床科学会议。 SWOG SDMC有助于实现SWOG及其与NCTN的合作伙伴在 目前的投资组合，同时也为其他临床试验提供数据、策略和有用的新统计工具 组织和肿瘤学研究人员。

Project Summary/Abstract Overall Component The SWOG Statistics and Data Management Center (SDMC) provides leadership in the statistical design, data management, analysis, and reporting of NCTN clinical trials. It contributes to SWOG's overall mission to significantly improve lives through cancer clinical trials and translational research. The goals of the SDMC are to (a) rapidly design, develop, and implement rigorous and efficient multi-center clinical trials; (b) enhance systems for best monitoring of ongoing trials and ensure reproducibility of research using cross-study standardized software and systems for statistical analysis and clinical trials reporting; (c) develop innovative statistical design and software tools for incorporating integral and integrated biomarkers into clinical trials; (d) collaborate with other researchers on statistical methods research, including clinical trial design and the analysis of translational medicine studies, with a focus on precision medicine and challenges in the evaluation of immunotherapy; (e) investigate new strategies for enhancing NCTN data by constructing linkages to external databases and building a comprehensive repository of SWOG clinical and translational medicine data; and (f) advance the science of the NCTN program and the National Cancer Institute research agenda, in partnership with other NCTN investigators, by providing scientific leadership through participation in activities such as steering committees, working groups, task forces, data sharing, and clinical science meetings. The SWOG SDMC contributes to the goals of SWOG and partners with the NCTN to conduct trials within the current portfolio, while also providing data, strategies, and useful new statistical tools to other clinical trials organizations and oncology researchers.