PIPELINE Facility Core

摘要：管道设施核心 通过利用仪器仪表、NextGen和 新兴技术（PIPELINE）的核心是推进精确的环境健康研究， 提供获得专门知识和技术的机会，并促进有效利用“omic” 技术，在GC-CPEH的上级组织。PIPELINE Facility Core提供 高效的系统级访问，使所有三个专题重点领域的研究人员能够将多个 下一代“组学”技术的研究。这样一来，PIPELINE Core将提供无缝访问 GC-CPEH研究基地的技术和机构之间的资源和数据集成。 PIPELINE资源包括：1）CellOmics（高通量和高内容成像和筛选，2） 基因组学，表观基因组学和转录组学，3）蛋白质组学，4）代谢组学，5）微生物组学和 宏基因组学和6）MultiOmic数据分析。为了利用这些资源，管道设施核心1） 为中心成员提供咨询，以确定最先进的技术，以满足他们的研究 目标; 2）实现高效的项目设计和全面的数据生成;以及，3）提供强大的 生物信息学分析和数据解释集成多个平台，最终提供系统级 知识重要的是，专题专家为资源的获取和利用提供便利， GC-CPEH成员的资源导航器。资源导航员优先考虑访问，并协助成员 项目设计、数据生成和信息分析。该核心还支持教育需求 通过研讨会和讲习班使用“组学”方法的GC-CPEH成员， 核心利用计划，以降低服务成本，并参与职业发展领导者在 培训计划。以下具体目标旨在确保管道设施核心实现 为个人研究者和跨中心推进精确环境健康研究的目标 合作。 具体目标1：提供高质量、用户友好的“组学”资源，加速精准环保 卫生研究和增加GC-CPEH研究基地的影响。 具体目标2：促进利用有助于职业发展的多种“组学”资源， 有前途的新调查员，并使高级调查员能够利用新技术。 具体目标3：通过促进GC-CPEH研究，增强环境健康特性和影响 合作，为高影响力的出版物做出贡献，并为EHS获得校外资助 research.

ABSTRACT: PIPELINE FACILITY CORE The Overall Goal of the Promoting Impact of Precision EHS by Leveraging Instrumentation, NextGen and Emerging Technologies (PIPELINE) Core is to advance precision environmental health research by providing access to expertise and technologies, and facilitating effective utilization of “omic” technologies, across the parent organizations of the GC-CPEH. The PIPELINE Facility Core provides efficient systems level access, enabling researchers from all three Thematic Focus Areas to incorporate multiple NextGen “omics” technologies into their research. In so doing, the PIPELINE Core will provide seamless access to resources and data integration across technologies and institutions of the GC-CPEH research base. PIPELINE resources are 1) CellOmics (high-throughput and high-content imaging and screening, 2) Genomics, Epigenomics and Transcriptomics, 3) Proteomics, 4) Metabolomics, 5) Microbiome and Metagenomics and 6) MultiOmic Data Analysis. To utilize these resources, the PIPELINE Facility Core 1) provides consultation to Center members to identify the best state-of-the-art technologies to meet their research goals; 2) enables efficient project design and comprehensive data generation; and, 3) provides robust bioinformatic analyses and data interpretation integrating multiple platforms to ultimately provide systems-level knowledge. Importantly, resource access and utilization are facilitated by subject-matter experts serving as Resource Navigators for GC-CPEH members. Resource Navigators prioritize access, and assist members with project design, data generation and informatics analyses. This Core also supports the educational needs of GC-CPEH members using “omics” methods through seminars and workshops, access to the Matching Funds Core Utilization Program to reduce cost of services, and participation in the Career Development Leader-in- Training program. The following Specific Aims are designed to ensure the PIPELINE Facility Core achieves the goal of advancing precision environmental health research for both individual investigators and cross-Center collaborations. Specific Aim 1: Provide high-quality, user-friendly “omics” resources to accelerate precision environmental health research and increase the impact of the GC-CPEH research base. Specific Aim 2: Facilitate utilization of multiple “omic” resources that contributes to career development of promising new investigators, and enables utilization of new technologies by senior investigators. Specific Aim 3: Enhance the environmental health identity and impact of GC-CPEH research by facilitating collaboration, contributing to high-impact publications, and acquiring extramural grant support for EHS research.