Coordinating center for collaborative marmoset research

项目摘要/摘要 常见的绒猴(Callithrix Jacchus)已经成为一种极其重要和容易驯服的非人类 适用于神经科学研究的灵长类(NHP)模型，包括遗传操作和定向繁殖。 神经科学界采用绒猴模型存在几个障碍，包括一个小的 美国人口普查规模(不到2500只动物)，关于资源可获得性的沟通不畅， 对绒猴在研究中的优势和局限性认识不足，缺乏正式的结构 协调与绒猴研究有关的信息和资源的共享。 在本申请中，我们建议建立一个Marmoset协调中心(MCC)，作为NIH大脑的一部分 通过推进创新神经技术(大脑)计划进行研究，以解决这些限制 通过建立我们在NHP信息学和绒猴研究方面的经验。作为MCC的基础，我们 将建立一个新的信息学框架，以协调基于LabKey数据的绒猴研究 管理系统。此基础架构将从多个位置的现有LabKey系统派生 国家灵长类研究中心，该中心已经为包括绒猴在内的NHP研究进行了优化， 经过多年的生产。该信息系统将使用有关绒猴的基本统计数据进行初始化 由参与中心提供的实验室人口，制作预先记录的个人级别的信息， 已经被记录下来，更广泛地提供给神经科学界。人口统计和遗传 信息将在参与中心之间共享和讨论，以协调绒猴群体 管理符合美国动物协会实践指南。 一旦投入使用，MCC将由两部分组成：1)基于Web的门户，以提供访问 LabKey中存储的绒猴数据资源，以及关于绒猴生物学和 神经科学；2)由MCC工作人员组成的礼宾，并增加了一个绒猴科学顾问委员会 神经科学专家。该网站将提供现有绒猴神经科学项目的摘要，以及 允许感兴趣的调查人员搜索动物清单并请求动物。礼宾部将可为 回答有关该中心和绒猴在神经科学中的使用的基本问题。总而言之，数据和 MCC的人力资源将通过以下方式提供进入绒猴神经科学研究的重要门户 合作、服务协议或动物转移。

PROJECT SUMMARY/ABSTRACT The common marmoset (Callithrix jacchus) has emerged as a critically important and tractable non-human primate (NHP) model for neuroscience research accommodating genetic manipulation and directed breeding. Several barriers to the adoption of marmoset models by the neuroscience community exist, including a small census size in the United States (fewer than 2,500 animals), poor communication about resource availability, a poor understanding of the strengths and limitations of marmosets in research, and a lack of a formal structure for coordinating the sharing of information and resources related to marmoset research. In this application, we propose to establish a Marmoset Coordinating Center (MCC) as part of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative that will address these limitations by building upon our experience in NHP informatics and marmoset research. As the foundation for the MCC, we will build a new informatics framework for coordinating marmoset research based on the LabKey data management system. This infrastructure will be derived from the existing LabKey system in place at multiple National Primate Research Centers, and which has been optimized for NHP research, including marmosets, over years of production. This informatics system will be initialized with basic statistics on the marmoset laboratory populations provided by participating centers, making pre-recorded, individual-level information that is already recorded more broadly available to the neuroscience community. Demographic and genetic information will be shared and discussed among participating centers, to coordinate marmoset colony management in line with American Zoological Association practice guidelines. Once operational, the MCC will be comprised of two parts: 1) a web-based portal to provide access to the marmoset data resources stored in LabKey, as well as background content on marmoset biology and neuroscience; 2) a concierge comprised of MCC staff and augmented by a scientific advisory board of marmoset neuroscience experts. The website will provide summaries of existing marmoset neuroscience projects, and allow interested investigators to search animal inventory and request animals. The concierge will be available to answer basic questions about the Center and the use of marmosets in neuroscience. Together, the data and human resources of the MCC will provide an essential portal into marmoset neuroscience research through collaboration, service agreement, or animal transfer.