Administrative Core

总结 行政核心将通过以下方式协调CAMPP AViDD中心：1）建立组织 以执行委员会为中心的结构，沿着主任、副主任 和科学顾问委员会（SAB）-监测整个计划的进展，并作出决定， 人员配备计划、资源分配、核心使用和其他政策; 2）协调定期举行的 中心的研究团队之间的电话会议，并组织年度会议， PI、选定的关键人员、SAB和NIAID，以及NIAID的年度反向现场访问; 3） 协助本联合体研究者进行试剂和数据共享、手稿准备、IND 筹备工作、及时公开传播数据以及提交年度进展报告， NIAID;以及4）为早期职业研究科学家和已建立的调查人员提供支持， 在其他领域发展抗病毒药物研究和开发的独立研究技能， 实施发展研究项目和指导项目计划。核心导演 在协调计划项目和大型多机构合作方面具有重要的专业知识 财团。他曾担任HINT联盟的主任，该联盟是一个由13名PI组成的项目 在10个专注于基于系统的艾滋病毒免疫反应分析的机构（P01 AI 090935）， 并担任其他多机构联盟的副主任; Fluomics（U19 AI 106754）和 Fluomics：下一代（U19 AI 135972），专注于系统级技术的使用 确定流感和SARS-CoV-2病毒发病机制的宿主决定因素。最近， 他被任命为多PD/PI NIAID疫苗佐剂发现计划合同的PD/PI （75 N93019 C 00046），多重PD/PI NIAID逆转HIV-1免疫功能障碍的PD/PI 根除计划（UM 1 AI 164561）和国防部发展与进步计划的PD 广谱呼吸道抗病毒药物（达布拉）（W81 XWH-20-1-0270）。核心副主任博士 García-Sastre是两个Fluomics项目以及达布拉项目的PD 因此，非常适合协助陈达博士成功地领导这一多- 纪律程序。García-Sastre副主任将监督将于2010年启动的指导项目。 2年，他在组织非常成功的Fluomics计划的经验，为初中支持 调查员（EMBED）。副主任阿纳·查特吉博士将负责监督 发展研究计划，并有丰富的经验，相关的发展 和具体的抗病毒药物和相关的基础科学研究的进步，有先进的多个 与百时美施贵宝，艾伯维， 和吉利德以及临床试验。

SUMMARY The Administrative Core will coordinate the CAMPP AViDD Center by 1) establishing an organizational structure centered on an Executive Committee responsible for – along with Director, Deputy Directors, and Scientific Advisory Board (SAB) – monitoring overall program progress and making decisions on staffing plans, allocation of resources, core usage, and other policies; 2) coordinating regularly held conference calls between the Center’s research teams and organizing annual meetings between the PIs, selected key personnel, the SAB and NIAID, as well as annual reverse site visits at NIAID; 3) assisting the investigators of this consortium in reagent and data sharing, manuscript preparations, IND preparations, the timely public dissemination of data, and the submission of annual progress reports to NIAID; and 4) providing support to early career research scientists and established investigators in other fields to develop independent research skills in antiviral drug research and development by implementing Developmental Research Projects and Mentored Project Programs. The Core Director has significant expertise in the coordination of program projects and large-scale multi-institutional consortia. He served as Director of the HINT consortium, a program project consisting of over 13 PIs at 10 institutions focusing on systems-based analysis of immune responses to HIV (P01 AI090935), and as Deputy Director of additional multi-institutional consortia; Fluomics (U19 AI106754) and Fluomics: The Next Generation (U19 AI135972), which focus on the use of systems-level technologies to identify host determinants of viral pathogenesis, both for influenza and SARS-CoV-2. More recently, he was named the PD/PI on a multi-PD/PI NIAID Vaccine Adjuvant Discovery Program contract (75N93019C00046), the PD/PI on the multi-PD/PI NIAID Reversing Immune Dysfunction for HIV-1 Eradication Program (UM1 AI164561), and the PD of the DoD program Development and Advancement of Broad-Spectrum Respiratory Antivirals (DABRA) (W81XWH-20-1-0270). Core Deputy Director Dr. García-Sastre has been the PD of the two Fluomics programs as well as the DABRA program mentioned above and is thus very well suited to assist Dr. Chanda in successfully leading this multi- disciplinary program. Deputy Director García-Sastre will oversee the Mentored Project to be initiated in year 2, supported by his experience in organizing the highly successful Fluomics program for junior level investigators (EMBED). Deputy Director Dr. Arnab Chatterjee will take responsibility for oversight of the Developmental Research program and has substantial experience relevant to the development and advancement of specific antivirals and related basic science studies, having advanced multiple drug candidates to major technology development licensing deals with Bristol-Myers Squibb, AbbVie, and Gilead as well as clinical trials.