Mentoring in Patient-Oriented Neuroscience Research

项目摘要 我是一名临床研究员，也是成瘾和心理健康神经发育实验室的主任。 在姆克林医院我也是哈佛医学院的精神病学副教授。我一直在 作为主要研究者（PI）持续资助进行NIAAA赞助的以患者为导向的研究 (POR)自2004年以来，他一直是NIH赞助的多项赠款的合作者和顾问。我 研究重点是了解青少年的大脑发育，以及青少年大脑发育的风险和潜在的神经生物学。 成瘾和精神疾病。在K24项目的头5年期间，我为50人提供了指导 从本科生到精神病学住院医师和初级教员。这些学员有 取得了显著的成绩，包括发表论文，提交赠款申请和晋升。我工作 在丰富的临床研究环境中，这是提供POR指导的理想选择。因为我没有收到 为辅导提供机构支持，并将需要减少辅导工作， 研究责任，K24更新将继续提供受保护的时间，使我能够保持 增加对学员的密集指导，并吸引新的研究学员加入POR。我的直系 长期的职业目标是继续描述成瘾的神经生物学标志物， 精神疾病，这将为开发新的有效治疗酒精使用提供信息 疾病和双重诊断的个人，并培训下一代研究人员， 有效开展POR所需的技能。我仍然致力于传播研究成果 （通过出版物、科学讲座和公众宣传），并在公开场合向受训人员提供辅导 外展，其目标是提供有关酒精研究的教育，这反过来将有助于预防 努力和知情的治疗干预措施，以帮助减少因酒精使用和滥用造成的痛苦。 在授予期间要实现的具体目标是：1）提供实质性的指导， 初级调查员和POR受训人员（35%），重点是辅导代表性不足的少数族裔受训人员; 2)继续并扩大参与我的POR（10%），以及3）提升我在内容领域的专业知识， 青少年共病精神病理学，青少年治疗的临床方法，并进行研究 在弱势青少年和成年人中，包括在种族/族裔上处于不利地位的青年和 引导性别认同发展，两者都有心理健康差异的证据（5%）。 尽管COVID-19大流行带来了挑战，但这些指导关系继续 成长，受训者在通往POR的道路上迈出了重要的步伐。我仍然坚定地致力于 继续培训一群杰出的学员，他们是成瘾和精神病学POR的未来。 通过密集的指导，我将通过增加我的临床观点来提高我的POR， 将治疗和多元文化考虑纳入我的POR计划。

PROJECT SUMMARY I am a clinical researcher and Director of the Neurodevelopmental Laboratory on Addictions and Mental Health at McLean Hospital. I also am an Associate Professor in Psychiatry at Harvard Medical School. I have been continuously funded as a principal investigator (PI) to conduct NIAAA-sponsored patient-oriented research (POR) since 2004 and have been a collaborator and consultant on multiple NIH-sponsored grants. My research focusing on understanding adolescent brain development, and risk for and underlying neurobiology of addiction and psychiatric disorders. During the first 5-year K24 period, I provided mentoring to 50 individuals ranging in rank from undergraduates through psychiatry residents and junior faculty. These mentees have made notable success, including publishing papers, submitting grant applications and being promoted. I work in a rich environment for clinical research, which is ideal for providing mentoring in POR. As I receive no institutional support for mentoring and will be required to curtail mentoring efforts to assume significant non- research responsibilities, a K24 renewal will continue to provide protected time that would allow me to maintain and increase my intensive mentorship to trainees, and attract new research mentees to POR. My immediate and long-term career objectives are to continue characterizing neurobiological markers in addiction and psychiatric disorders, which will inform the development of new and effective treatments for alcohol use disorders and for individuals with dual diagnoses, and to train the next generation of investigators to develop the skills they require to effectively conduct POR. I remain committed to disseminating research findings (through publications, scientific lectures and public outreach) and provide mentoring to trainees in public outreach, the goal of which is to provide education around alcohol research, which in turn will help prevention efforts and inform treatment interventions, to aid in the reduction of suffering due to alcohol use and abuse. The specific aims to be accomplished during the period of the award are to 1) provide substantive mentoring of junior investigators and trainees in POR (35%), with a focus on mentoring underrepresented minority trainees; 2) continue and extend involvement in my POR (10%), and 3) advance my expertise in the content areas of adolescent comorbid psychopathology, clinical approaches in adolescent treatment, and conducting research in vulnerable adolescent and adult populations, including racial/ethnically disadvantaged youth and those navigating gender identity development, both with established evidence of mental health disparities (5%). Despite the challenges imposed by the COVID19 pandemic, these mentoring relationships have continued to grow, and trainees are making significant strides in their paths toward POR. I remain deeply committed to the continued training of a remarkable group of mentees, who are the future of addiction and psychiatry POR. Through intensive mentoring I will enhance my POR by increasing my clinical perspectives, and by incorporating treatment and multicultural considerations into my POR initiatives.