Consequences of Adolescent Alcohol Use on Brain Development

青少年饮酒对大脑发育的影响

• 批准号: 8723602
• 负责人: MARISA M SILVERI
• 金额: $ 54.77万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-05 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8723602
• 关键词: Adolescent; Adolescent Medicine; Age; Age of Onset; Alcohol consumption; Alcohol or Other Drugs use; Anisotropy; Anterior; Behavior assessment; Boston; Brain; Clinic; Clinical; Clinical assessments; Cognitive; Core-Binding Factor; Data; Development; Diffusion Magnetic Resonance Imaging; Drug usage; Enrollment; Failure; Female; Female Adolescents; Foundations; Functional Magnetic Resonance Imaging; Glutamates; Hippocampus (Brain); Hyperactive behavior; Image; Imaging Techniques; Machine Learning; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male Adolescents; Measurement; Measures; Medial; Mediating; Memory; Methods; Metric; Modeling; Multimodal Imaging; Neuronal Plasticity; New England; Outcome; Pattern; Pediatric Hospitals; Performance; Perfusion; Preventive Intervention; Primary Health Care; Process; Recruitment Activity; Relative (related person); Research; Rest; Sampling; Signal Transduction; Spin Labels; Substance abuse problem; Task Performances; Temporal Lobe; Time; Visit; adolescent alcohol; adolescent substance abuse; age related; alcohol and other drug; alcohol use initiation; base; blood oxygen level dependent; cingulate cortex; critical period; design; early alcohol use; follow-up; gamma-Aminobutyric Acid; improved; innovation; insight; male; myelination; neuroimaging; neuropsychological; pediatrician; practice-based research network; public health relevance; reduce adolescent alcohol; relating to nervous system; response; sex; underage drinking; way finding; white matter

DESCRIPTION (provided by applicant): This revised R01 A1 proposal (AA022493), "Consequences of Adolescent Alcohol Use on Brain Development", responds to the need to understand the impact of initiating alcohol consumption on adolescent brain maturation. We have teamed with the Center for Adolescent Substance Abuse Research (CeASAR) and Boston Children's Hospital to implement an innovative strategy that combines multiple neuroimaging and neuropsychological approaches to identify neurodevelopmental vulnerabilities associated with early and escalating alcohol use during adolescence. Adolescents will be recruited from general pediatrician offices and adolescent medicine clinics comprising the New England Partnership for Substance Abuse Research (NEPSAR), a practice-based research network of primary care offices. Adolescents will be enrolled into the study prior to the initiation of alcoho use or other drug use, and examined longitudinally, at baseline (13-14 yrs old) and again at two annual follow-up visits. To provide a comprehensive longitudinal profile of brain function, structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and task and resting state blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) will be paired with magnetic resonance spectroscopy (MRS) to measure GABA and glutamate levels in the anterior cingulate cortex (ACC) and medial temporal lobe (MTL, containing hippocampus). In addition, arterial spin labeling (ASL) will be used to measure quantitative perfusion, which will be used to calibrate the magnitude of BOLD fMRI signal changes during response inhibition and spatial memory fMRI tasks. Magnetic resonance measures will be integrated with measures from clinical assessments and an extensive neuropsychological battery, designed to detect and further characterize developmental changes and the influence of adolescent alcohol use. The incorporation of complementary multi-modal measures of brain function and neuroplasticity could offer valuable insight into the dynamic processes of brain maturation and help identify neural signatures associated with the onset and escalation of alcohol use, which will provide a foundation for informing prevention and intervention efforts aimed at reducing adolescent alcohol consumption.

描述（由申请人提供）：本修订版R 01 A1提案（AA 022493）“青少年饮酒对大脑发育的影响”，响应了了解饮酒对青少年大脑成熟的影响的需求。我们与青少年药物滥用研究中心（CeASAR）和波士顿儿童医院合作，实施了一项创新战略，该战略结合了多种神经成像和神经心理学方法，以确定与青春期早期和不断升级的酒精使用相关的神经发育脆弱性。青少年将从普通儿科医生办公室和青少年医学诊所招募，这些诊所包括新英格兰药物滥用研究伙伴关系（NEPSAR），这是一个以实践为基础的初级保健办公室研究网络。青少年将在开始使用酒精或其他药物之前被纳入研究，并在基线（13-14岁）和两次年度随访时进行纵向检查。为了提供脑功能的全面纵向概况，将结构磁共振成像（MRI）、扩散张量成像（DTI）以及任务和静息状态血氧水平依赖性（BOLD）功能磁共振成像（fMRI）与磁共振波谱（MRS）配对，以测量前扣带皮层（ACC）和内侧颞叶（MTL，含海马）中的GABA和谷氨酸水平。此外，动脉自旋标记（ASL）将用于测量定量灌注，其将用于校准响应抑制和空间记忆fMRI任务期间BOLD fMRI信号变化的幅度。磁共振测量将与临床评估和广泛的神经心理电池的测量相结合，旨在检测和进一步表征青少年饮酒的发展变化和影响。结合脑功能和神经可塑性的补充多模态测量可以提供有价值的洞察大脑成熟的动态过程，并帮助识别与酒精使用的开始和升级相关的神经特征，这将为旨在减少青少年饮酒的预防和干预工作提供基础。