Mentoring in Patient-Oriented Neuroscience Research

以患者为导向的神经科学研究的指导

• 批准号: 9757593
• 负责人: MARISA M SILVERI
• 金额: $ 15.13万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-08 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9757593
• 关键词: Abstinence; Adolescent; Alcohol abuse; Alcohol consumption; Anxiety; Applications Grants; Area; Award; Child Abuse and Neglect; Clinical; Clinical Research; Collaborations; Comorbidity; Data Set; Development; Development Plans; Doctor of Philosophy; Environment; Epigenetic Process; Faculty; Foundations; Funding; Future; Goals; Grant; Hospitals; Intervention; Laboratories; Mental Health; Mental disorders; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Monitor; National Center for Complementary and Alternative Medicine; National Institute of Drug Abuse; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Neurobiology; Neurosciences Research; Patients; Prevention; Principal Investigator; Psychiatry; Psychopathology; Public Health; Publications; Research; Research Personnel; Risk; Time; Training; Trust; United States National Institutes of Health; Work; addiction; adolescent brain development; adolescent patient; alcohol use disorder; binge drinker; career; career development; dual diagnosis; effective therapy; emerging adult; interest; lectures; medical schools; mid-career faculty; next generation; outreach; patient oriented; patient oriented research; patient population; programs; secondary analysis; skills

PROJECT SUMMARY I am a clinical researcher and Director of the Neurodevelopmental Laboratory on Addictions and Mental Health at McLean Hospital. I also am an Associate Professor in Psychiatry at Harvard Medical School. I have been continuously funded as a principal investigator (PI) to conduct NIAAA-sponsored patient-oriented research (POR) since 2004 and have been a collaborator and consultant on several additional NIH-sponsored grants. My research has focused on understanding adolescent brain development, and risk for and underlying neurobiology of addiction and psychiatric disorders. I currently serve as PI on one NIAAA R01 grant and one Foundation grant, and am Co-Investigator on 3 R01s (NIMH, NCCAM, NIDA) and 1 R21 (NIAAA). I mentor a growing group of junior investigators, including 3 mentees on K01 grants. I work in a rich environment for clinical research, which is ideal for training junior faculty in POR. However, I receive no institutional support for mentoring and will be required to curtail mentoring efforts to assume significant non-research responsibilities beginning in 2017. The K24 award will protect time that would permit an increase in intensive mentorship to junior investigators and attract researchers to POR. My immediate and long-term career objectives are to characterize neurobiological markers in addiction and psychiatric disorders, which will inform the development of new and effective treatments for alcohol use disorders and for patients with dual diagnoses, and to train the next generation of investigators to develop the skills they require to effectively conduct POR. I also remain committed to disseminating research findings (through publications, scientific lectures and public outreach) that will help prevention efforts and that will inform treatment interventions, to aid in the reduction of suffering due to alcohol use and abuse. The specific aims to be accomplished during the period of the award are to 1) provide substantive mentoring of junior investigators in POR (35%), 2) continue and extend involvement in my POR (10%), and 3) develop specific new content expertise in the areas of adolescent comorbid psychopathology, clinical approaches in adolescent treatment settings, and epigenetics (5%). I am committed to training a remarkable group of mentees, who are the future of addiction and psychiatry POR. Through intensive mentoring I will, in turn, enhance my POR by increasing my clinical perspectives, and by incorporating treatment and epigenetic components into new POR initiatives.

项目总结 我是一名临床研究员，也是成瘾与心理健康神经发育实验室的主任 在麦克莱恩医院。我也是哈佛医学院的精神病学副教授。我一直在 作为首席研究员(PI)持续资助NIAAA赞助的以患者为中心的研究 自2004年以来，他一直是美国国立卫生研究院赞助的其他几项赠款的合作者和顾问。 我的研究重点是了解青少年的大脑发育，以及大脑发育的风险和潜在的 成瘾和精神障碍的神经生物学。我目前在一项NIAAA R01拨款和一项 基金会拨款，以及3个R01(NIMH、NCCAM、NIDA)和1个R21(NIAAA)的AM协查人员。我指导了一位 初级调查人员队伍不断壮大，其中包括3名K01资助金的学员。我在一个富裕的环境中工作 临床研究，这是培训初级教职员工POR的理想选择。然而，我没有得到任何机构的支持 指导，并将被要求减少指导工作，以承担重大的非研究责任 从2017年开始。K24奖将保护允许增加密集指导的时间 初级调查人员，并吸引研究人员到POR。我近期和长期的职业目标是 确定成瘾和精神障碍的神经生物学标记物的特征，这将为发展提供信息 为酒精使用障碍和双重诊断患者提供新的有效治疗方法，并培训 下一代调查人员需要发展他们有效进行POR所需的技能。我也会留下来 致力于传播研究成果(通过出版物、科学讲座和公众宣传)， 将有助于预防工作，并将为治疗干预提供信息，以帮助减少因以下原因造成的痛苦 酗酒和滥用。在授奖期间要实现的具体目标是：1)提供 在我的POR中对初级调查人员提供实质性指导(35%)，2)继续并扩大参与我的POR (10%)，以及3)在青少年共病精神病理学领域发展具体的新内容专门知识， 青少年治疗环境中的临床方法，以及表观遗传学(5%)。我致力于培训一名 一群杰出的受训者，他们是成瘾和精神病学POR的未来。通过密集的 反过来，指导我将通过增加我的临床视角，并通过纳入 将治疗和表观遗传成分纳入新的POR倡议。