Mental Health Research Network III

基于实践的研究有可能极大地提高速度、效率、相关性和影响力 心理健康临床和服务研究。要实现这些成果，需要一项以实践为基础的研究 能够预见和适应精神卫生保健提供的变化的网络，包括： ·研究完全融入现实世界的实践中 ·使研究目标与患者和卫生系统利益攸关方的优先事项保持一致 ·可用于快速分析的大规模数据基础设施 ·建立信任和透明的文化，促进协作学习和改进 我们建议将现有的精神卫生研究网络(MHRN)扩大到包括14个研究中心 嵌入到医疗系统中，为16个州超过2500万名患者提供服务。MHRN 基础设施将得到加强，以支持基于实践的下一代网络，包括： ·患者、卫生系统领导人和其他利益相关者更多地参与网络治理 ·扩大软件工具库和其他技术资源的公共开放源码库 ·开展可行性试点项目和快速回应利益攸关方询问的更正式程序 ·扩大与外部利益攸关方和研究伙伴的联系 这个整体应用程序请求支持一个管理核心、一个方法核心和四个研究 项目。行政核心将支持所有网络活动，包括正在进行的附属研究 项目、本申请中提出的新研究项目和未来开发的新项目 资金周期。组织单位将包括行政领导、治理、战略规划和 负责财务管理和监管合规。外展与外部协作 该单位将负责利益相关者的参与，并与新的研究伙伴开展合作。 新出现的问题股将支持及时应对新出现的科学和公共卫生问题。这个 方法核心将支持在所有网络研究中优化使用现有方法，并开发新的 解决高度优先的公共卫生问题的方法。一个信息学股将维持和改进 网络数据基础设施和传播网络开发的信息学资源。科学分析 该单位将专注于提高网络项目的方法严谨性和创新分析的发展 由利益相关者需求驱动的方法。这些基础设施资源将支持两项标志性研究 项目(针对围产期抑郁症的电子健康干预的务实试验和对新的 解决自杀风险的药物)和两个试验性研究项目(对利益相关者的调查 关于实施自杀风险预测模型和外展试点以减少自杀风险的观点 抑郁症治疗启动方面的差异)。

Practice-based research has the potential to dramatically improve the speed, efficiency, relevance, and impact of mental health clinical and services research. Realizing those gains will require a practice-based research network capable of anticipating and adapting to changes in mental health care delivery, including: • Research fully embedded in real-world practice • Alignment of research goals with priorities of patient and health system stakeholders • Large-scale data infrastructure available for rapid analysis • A culture of trust and transparency to facilitate collaborative learning and improvement We propose to expand the existing Mental Health Research Network (MHRN) to include 14 research centers embedded in health systems serving a combined population of over 25 million patients in 16 states. MHRN infrastructure will be enhanced to support a next-generation practice-based network, including: • Increased engagement of patients, health system leaders, and other stakeholders in network governance • An expanded public, open-source library of software tools and other technical resources • More formal processes for conducting feasibility pilot projects and rapid response to stakeholder queries • Expanded outreach to external stakeholders and research partners This Overall application requests support for an Administrative Core, a Methods core, and four research projects. The Administrative Core will support all network activities, including ongoing affiliated research projects, new research projects proposed in this application, and new projects developed during the coming funding cycle. An Organizational Unit will include executive leadership, governance, strategic planning, and responsibility for financial management and regulatory compliance. An Outreach and External Collaboration Unit will be responsible for stakeholder engagement and developing collaborations with new research partners. An Emerging Issues Unit will support timely responses to emerging scientific and public health questions. The Methods Core will support optimal use of existing methods across all network research and develop new methods to address high-priority public health questions. An Informatics Unit will maintain and improve network data infrastructure and disseminate network-developed informatics resources. A Scientific Analysis Unit will focus on improving the methodologic rigor of network projects and development of innovative analytic methods driven by stakeholder needs. These infrastructure resources will support two Signature research projects (a pragmatic trial of eHealth interventions for perinatal depression and a real-time evaluation of new medications to address suicide risk) and two Pilot research projects (an investigation of stakeholder perspectives on implementation of suicide risk prediction models and a pilot trial of outreach to reduce disparities in depression treatment initiation).