Mentoring in Translational Malaria Genomics

项目摘要 博士Jonathan Juliano是国际公认的疟疾研究领导者，也是将下一代测序技术用于应用基因组学项目的先驱。他是查佩尔山的北卡罗来纳州大学传染病系的教授，在那里他帮助建立了一个主要的转化疟疾研究中心。自2010年以来，他一直获得NIH的独立资助。Juliano博士致力于以患者为导向的研究（POR）的学术生涯，他和他的学员解决与疟疾控制直接相关的问题，他被公认为杰出的导师，因其指导学员的良好记录而获得UNG久负盛名的2016年学士后教学杰出教学奖，重点是传染病研究员和医学博士/博士生参与POR的学生他的K24奖的拟议更新将使Juliano博士能够发展新的研究技能，通过获得空间和传输建模的技能来提高他的研究专业知识和指导。疟疾，通过学习有效领导的策略，并建立在他的K24开发的辅导技能。特别是，他将新的重点是专门通过正式和非正式的指导指导不同群体的学员的技能。为了促进学员的职业发展，Juliano博士将利用UNG提供的广泛培训资源，包括NC转化和临床科学研究所，Gillings全球公共卫生学院和医学院。Juliana博士参与这些项目，以及医学博士/博士项目和UNG传染病奖学金项目，确保他能够很好地招募和指导学员。拟议的CAMMM研究（疟疾运动方法的比较分析）将通过更好地了解寄生虫在不同传播环境中如何在空间中移动来帮助消除疟疾议程，了解寄生虫迁移和传播的空间动态可以帮助确定干预热点，定义输入，并为预测耐药性传播的模型提供信息。然而，为了实现这一目标，需要更好地了解哪些基因组方法在不同的位置和传播强度下起作用。结合基因分型的进步与培训的空间和传输建模虽然说教和指导经验在帝国理工学院伦敦将提供博士Juliano和他的导师加强他们的研究和转化为可操作的信息他们的基因组发现的能力。拟议的K24将允许Juliano博士开发一个研究平台，这是他以前工作的自然延伸，将导致疟疾传播研究的重大方法进步，将提高他的指导技能，以确保所有学员的公平环境，并将建立新的研究机会，以促进职业发展和POR学员和年轻教师的指导。

PROJECT SUMMARY Dr. Jonathan Juliano is an internationally recognized leader in malaria research and a pioneer in the use of next generation sequencing technologies for applied genomics projects. He is a Professor in the Division of Infectious Diseases at the University of North Carolina at Chapel Hill, where he has helped to establish a major center for translational malaria research. He has had continuous independent NIH funding since 2010. Dr. Juliano is committed to an academic career in patient-oriented research (POR), in which he and his trainees address problems with direct relevance to malaria control, He is recognized as an outstanding mentor, having received the prestigious 2016 Distinguished Teaching Award for Post-Baccalaureate Instruction at UNG for his strong record of mentoring trainees, which focuses on Infectious Disease fellows and MD/PhD students students involved in POR The proposed renewal of his K24 award will allow Dr. Juliano to develop new research skills to enhance his research expertise and mentorship by gaining skills in spatial and transmission modeling of malaria, by learning strategies for effective leadership, and by building on the mentoring skills developed in his K24. In particular, he will newly focus on skills specifically for mentoring diverse groups of trainees through both formal and informal guidance. To foster the career development of his trainees, Dr. Juliano will leverage the extensive training resources available at UNG, including the NC Translational and Clinical Sciences Institute, the Gillings School of Global Public Health, and the School of Medicine. Dr. Juliana's involvement in these programs, as well as the School of Medicine MD/PhD program and the UNG Infectious Diseases Fellowship program, ensures that he will be well positioned to recruit and mentor trainees. The proposed CAMMM study (Comparative Analysis of Methods for Malaria Movement) will aid the malaria elimination agenda by providing a better understanding of how parasites move in space in different transmission settings, Understanding the spatial dynamics of parasite migration and transmission can help define hot spots for intervention, define importation, and inform models to predict the spread of resistance. However, to realize this goal, a better understanding of what genomic methods work in different locations and transmission intensities is needed. Combining advances in genotyping with training in spatial and transmission modeling though didactic and a mentored experience at Imperial College London will provide Dr. Juliano and his mentees the ability to strengthen their research and translate their genomic findings into actionable information. The proposed K24 will permit Dr. Juliano to develop a research platform that is a natural extension of his previous work, will result in a significant methodological advance for the study of malaria transmission, will enhance his mentoring skills to ensure an equitable environment for all trainees, and will establish new research opportunities to foster the career development and mentoring of trainees and young faculty members in POR.