Renal Disease Epidemiology Training Grant

肾脏疾病非常普遍，会导致过早死亡、并存疾病、质量下降 生命，以及高昂的医疗费用。考虑到肾脏疾病流行的广泛范围，有一个关键的 需要培训能够进行高影响力研究的科学家，以解决这一大规模的健康问题。 这项提案是一项竞争性续签申请，年限为26至30年，要求NRSA为我们的肾脏疾病提供资金 霍普金斯大学流行病学和临床研究培训计划。该计划的目标是识别和 培养有潜力成为流行病学、临床设计和实施领域领导者的科学家 以及与肾脏疾病相关的翻译研究。该计划的总部设在韦尔奇中心 预防、流行病学和临床研究。它利用了教职员工在 应用严谨的方法论研究肾脏疾病；他们设计跨学科、高影响力的能力 研究；以及他们对教育和指导的奉献。项目主任(阿佩尔博士)，助理 董事(Fadrowski博士、Grams博士、Segev博士)和其他14名国家公认的肾脏疾病研究人员 作为核心教员，另外11名教员担任附属教职。机构咨询委员会 领导者和有经验的研究人员为该项目的领导层提供建议，并监督其进展。 我们的培训计划非常成功。我们招募了非常高素质的候选人， 为他们提供了严格的培训，并帮助他们开始了研究生涯。在过去15年中，我们 支持了31名博士后实习生(77%为女性，10%为代表不足的少数族裔)。在25名毕业生中，有24人 正在追求学术生涯，其中绝大多数是科学家；12人获得了联邦拨款(11K 获奖者)。NRSA的资金使霍普金斯大学成为一个卓越的设计和学术中心 进行与肾脏疾病有关的临床、流行病学和翻译研究；催生新的研究 方案(例如CKD预后联盟和肾脏移植结局方案)和新的 教育举措(例如肾脏疾病流行病学课程)；振兴儿科肾脏病研究金； 在学校和学术单位之间建立了密切的合作关系；最重要的是， 一群非常成功的年轻研究人员，他们在世界各地的机构进行创新研究 尽管如此，我们不会固步自封。有了这项申请的资金，我们打算增加 我们的培训计划从4名博士后实习生增加到6名，扩大了核心教员(包括招聘的杰出人才 来自其他机构的D·布伦南、C·丘特和C·帕里克)，并加强实习生招募工作， 特别针对招收代表性不足的少数族裔。最终，这款T32将满足以下关键目标 NIDDK，即扩大训练有素的研究人员队伍，进行有影响力的肾脏疾病研究。

Kidney disease is highly prevalent and results in premature mortality, comorbid illnesses, reduced quality of life, and substantial healthcare costs. Given the vast scope of the kidney disease epidemic, there is a critical need to train scientists who can conduct high-impact research that addresses this massive health problem. This proposal is a competitive renewal application, years 26 to 30, for a NRSA to fund our Kidney Disease Epidemiology and Clinical Research Training Program at Hopkins. The goal of this program is to identify and train scientists who have the potential to become leaders in the design and conduct of epidemiologic, clinical and translational research related to kidney disease. The Program is based in the Welch Center for Prevention, Epidemiology, and Clinical Research. It takes advantage of the faculty’s strengths in the application of rigorous methodology to study kidney disease; their ability to design interdisciplinary, high-impact research; and their dedication to education and mentorship. The program Director (Dr. Appel), Associate Directors (Drs. Fadrowski, Grams, Segev), and 14 other nationally recognized kidney disease researchers serve as core faculty, and another 11 faculty serve as affiliate faculty. An Advisory Committee of institutional leaders and accomplished researchers advise the program’s leadership and monitor its progress. Our training program has been highly successful. We have recruited exceptionally high-quality candidates, provided them with rigorous training, and helped launch their research careers. Over the last 15 years, we supported 31 post-doctoral trainees (77% women, 10% underrepresented minorities). Of the 25 graduates, 24 are pursuing academic careers, and the vast majority are scientists; 12 received federal grants (11 K awardees). The NRSA funding has established Hopkins as a pre-eminent academic center for the design and conduct of clinical, epidemiologic and translational research related to kidney disease; spawned new research programs (e.g. the CKD Prognosis Consortium and the Kidney Transplant Outcomes program) and new education initiatives (e.g. kidney disease epidemiology course); revitalized the Pediatric Nephrology fellowship; forged close collaborative relations across schools and academic units; and most importantly, produced a cadre of extremely successful young investigators who are doing innovative research at institutions across the U.S. Still, we will not rest on our laurels. With funding from this application, we intend to increase the size of our training program from 4 to 6 post-doctoral trainees, expand the core faculty (including luminaries recruited from other institutions: D. Brennan, C. Chute, and C. Parikh), and enhance trainee recruitment efforts, especially targeted at enrolling under-represented minorities. Ultimately, this T32 will meet a critical goal of NIDDK, i.e. broadening the pool of well-trained researchers conducting impactful kidney disease research.