Botswana-Harvard T.H. Chan School of Public Health AIDS Initiative Partnership CTU

摘要/摘要 这是一份更新博茨瓦纳临床试验单位（CTU）的申请，该单位将进行相关研究 成人和儿童艾滋病毒治疗策略;采取干预措施， 儿童和孕产妇感染/病症; 感染和未感染艾滋病毒的成人（包括孕妇）和儿童;以及艾滋病毒综合预防 儿童和成人人群的策略。 这些活动将通过参与三个研究网络进行：1）艾滋病毒/艾滋病成人研究网络， 治疗药物临床试验网络; 2）艾滋病毒/艾滋病孕产妇、青少年和儿童治疗药物 临床试验网络，以及3）艾滋病毒预防临床试验网络。我们将开展多中心 在我们的两个已建立的CRS进行研究：一个在博茨瓦纳首都哈博罗内（所有3个网络）， 另一个在Molepolole（仅限孕产妇、青少年和儿科治疗网络）， 博茨瓦纳的一个村庄。因此，我们将与所有年龄段的城乡人口合作， 性别 因此，这项建议的主要目标是在博茨瓦纳重新设立一个反恐股， 为以下高影响力的研究领域做出贡献： 成人（包括孕妇）和儿童的新型和持久的艾滋病毒治疗 在成人和儿童中诱导无抗逆转录病毒疗法的艾滋病毒缓解（或根除）的战略 成人和儿童艾滋病毒相关并发症和合并感染的治疗和预防 成人和儿童结核病的新治疗/模式和预防方法 * 艾滋病毒预防战略，包括接触前预防和综合预防办法 在这些研究领域中，该技术股将作出重大贡献： 招募参与者并进行高质量的临床研究， * 参加网络活动，包括礼宾小组和科学/资源委员会， 在优先领域构思和提出新的、相关的、高影响力的研究

Summary/Abstract This is an application to renew a Clinical Trials Unit (CTU) in Botswana that will conduct research related to adult and pediatric HIV therapeutic strategies; interventions to address HIV-associated infections/conditions in pediatric and maternal populations; treatment and prevention of tuberculosis in adults (including pregnant women) and children with and without HIV; and integrated HIV prevention strategies in pediatric and adult populations. These activities will occur through participation in three research networks: 1) the HIV/AIDS Adult Therapeutics Clinical Trials Network; 2) HIV/AIDS Maternal, Adolescent and Pediatric Therapeutics Clinical Trials Network, and 3) the HIV Prevention Clinical Trials Network. We will perform multi-center studies at our two established CRSs: one in Gaborone (all 3 networks), the capital city of Botswana, and the other in Molepolole (Maternal, Adolescent and Pediatric Therapeutics network only), the largest village in Botswana. We will thus work with both urban and village populations of all ages and of both sexes. The primary objective of this proposal is therefore to renew a CTU in Botswana that will participate in and contribute to the following high-impact areas of research:  Novel and durable treatments for HIV in adults (including pregnant women) and children  Strategies to induce ART-free HIV remission (or eradication) in adults and children  Treatment and prevention of HIV-related complications and co-infections in adults and children  New treatments / modalities and prevention approaches for tuberculosis in adults and children  HIV prevention strategies, including pre-exposure prophylaxis and integrated prevention approaches Within each of these research areas, this CTU will contribute significantly to:  Enrolling participants into and conducting high-quality clinical research studies,  Participating in network activities, including protocol teams and scientific / resource committees, and  Conceiving and proposing new, relevant, high-impact studies in priority areas