Nutrition Precision Health for All of Us (Chicago Center)

项目总结 流行病学和临床研究支持营养在健康中的重要作用。然而，营养研究 由于自我报告的饮食数据以及个体间和个体内的差异而产生的偏见限制了这一点。高吞吐量的“体型” 性能分析技术与先进的远程实时数据收集相结合，现在可以实现全面的 研究个体对饮食的反应，从而为个性化营养建议创造机会。 我们的总体目标是通过利用我们现有的 伊利诺伊州精密医学联盟(IPMC)基础设施招收我们所有人的研究计划(AoURP) 发现营养科学研究的参与者涉及三个饮食模块。建议对…进行调查 以血压(BP)为指标的饮食控制高血压(DASH)饮食的具体要素 主要结果。BP受到一个复杂的机制网络的调节，受遗传和 环境因素，高血压被认为是心血管疾病的主要可改变危险因素 世界范围内的疾病、脑血管疾病、肾脏疾病和全因死亡。DASH节食坚持 一直有记录表明，无论基线卡路里或钠摄入量如何，血压都有所降低。虽然年纪较大， 高血压和黑人对DASH依从性和低钠饮食的血压反应更强 在摄入量方面，观察到了个体间的差异，但仍无法解释。在模块1中，我们将跟踪2,000 AoURP参与者14天，检查基线饮食和对试餐挑战的生理反应 假设根据个体心脏代谢引起不同的生理和代谢反应， 遗传和肠道微生物状况。然后，我们检查了三个14天干预期的反应，包括 在自由生活控制喂养研究(模块1)中，400名同意的模块1参与者的DASH类型饮食 2)和200名参加户籍控制喂养研究的模块1参与者(模块3)。三大干预 饮食是等卡路里的，相当于钠，包括：i)DASH-标准，II)DASH-FFF，指定水果， 类黄酮、脂肪和DASH-PP，强调植物蛋白。每种饮食都有独特的营养特性， 影响BP调节，每个都将阐明不同的生理、代谢和微生物体反应 会受到心脏代谢和遗传状态的影响。我们的三个IPMC临床站点，包括西北大学 伊利诺伊理工大学、芝加哥大学和伊利诺伊理工学院在地理上分布广泛 在种族和社会经济多元化的芝加哥社区中提供独特的服务领域，从而提供 有针对性地招收人口结构不同的参与者。 这项与NPH联盟合作的研究启动了基本的因果和机械洞察力 Dash型饮食在血压调节中的作用及其可能发现的新的生物途径 开发高BP的潜在风险。这一先进的知识可以告知前所未有的个性化 预防和治疗高血压带来的巨大公共健康负担的饮食建议。

PROJECT SUMMARY Epidemiological and clinical studies support an important role of nutrition in health. However, nutrition research is limited by bias due to self-reported diet data and inter- and intra-individual variation. High-throughput `omic' profiling techniques combined with advanced remote real-time data collection now enable comprehensive studies of individual responses to diet thereby creating opportunities for personalized nutrition advice. Our overall goal is to facilitate the Nutrition for Precision Health (NPH) Consortium by leveraging our existing Illinois Precision Medicine Consortium (IPMC) infrastructure to enroll All of Us Research Program (AoURP) participants in the discovery nutrition science study involving three diet modules. Proposed is investigation of specific elements of a Dietary Approaches to Stop Hypertension (DASH) diet with blood pressure (BP) as the primary outcome. BP is regulated by a complex network of mechanisms under the influence of genetic and environmental factors, and high BP is recognized as the leading modifiable risk factor for cardiovascular disease, cerebrovascular disease, kidney disease and all-cause mortality worldwide. DASH diet adherence has consistently documented reduced BP, independent of baseline calorie or sodium intake. Although older, hypertensive and Black persons show greater BP responses to DASH adherence and reduced dietary sodium intake, inter-individual variability is observed and remains unexplained. In Module 1, we will follow 2,000 AoURP participants for 14 days to examine baseline diet and physiological responses to test-meal challenges hypothesized to elicit variable physiological and metabolomic responses based on individual cardiometabolic, genetic and gut microbial status. We then examine responses to three 14-day intervention periods involving DASH-type diets among 400 consenting Module 1 participants in a free-living controlled feeding study (Module 2) and in 200 Module 1 participants in a domicile controlled feeding study (Module 3). The three intervention diets are isocaloric, sodium equivalent and include: i) DASH-Standard, ii) DASH-FFF, specifying fruits, flavonoids and fat and DASH-PP, emphasizing plant protein. Each diet has distinctive nutritive properties that influence BP regulation and each will elucidate diverse physiological, metabolomic, and microbiomic responses that are modified by cardiometabolic and genetic status. Our three IPMC clinical sites including Northwestern University, the University of Chicago, and the Illinois Institute of Technology span wide yet geographically distinct service areas in ethnically and socioeconomically diverse Chicago communities, thereby offering targeted enrollment of demographically diverse participants. This research in collaboration with the NPH consortium initiates fundamental causal and mechanistic insight into the role of the DASH-type diet in BP regulation with potential to discover novel biological pathways underlying risks for developing high BP. This advanced knowledge can inform unprecedented personalized diet recommendations to prevent and treat the massive public health burden off hypertension.