CACHET - IHSFC

凯切特 - IHSFC

• 批准号: 10394643
• 负责人: Briseis A Aschebrook-Kilfoy
• 金额: $ 30.33万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394643
• 关键词: Chicago; Environment; Health

1. INTEGRATED HEALTH SCIENCES FACILITY CORE: ABSTRACT The Integrated Health Sciences Facility Core (IHSFC) will provide infrastructure and highly focused trans- disciplinary services to CACHET members including access to cohorts and bio-banking; environmental health sciences (EHS) design, implementation and translational study services; innovative approaches to population exposure estimation using both traditional and cutting-edge techniques including device, sensors and wearables and mobile app technologies; and novel statistical services with a focus on challenges in geospatial modeling and evaluation of mixtures. This array of services will provide tools to translate fundamental research into knowledge supporting disease prevention and the mitigation of racial/ethnic environmental health disparities. The IHSFC will have leadership at both University of Illinois at Chicago (UIC) and University of Chicago (UofC), and will build upon the existing research resources at these institutions to ensure that Core support is used to develop additional key resources for conducting EHS work. Many of the resources that the IHSFC uses to meet the EHS translational research needs of CACHET investigators that exist at our two institutions have been modified, enhanced, centralized and efficiently organized between the two institutions by leveraging the institution-specific strengths and growing Core resources. IHSFC personnel include experts in epidemiological study design, population and clinic-based studies, specimen collection and quality assurance, exposure technology and data analytics to support superior exposure assessment, and statistical methods relevant for modern environmental health studies. IHSFC personnel will collaborate with personnel in the Environmental Biomarkers Facility Core (EBC) to address molecular assay requirements involving biomarkers of environmental exposures and environmental signatures in human biological materials. The IHSFC will also provide interpretation of results and facilitate dissemination of the results to Chicago communities and beyond in conjunction with the Community Engagement Core (CEC). In addition, the IHSFC will work with the CEC as well as relevant Institutional CTSA and Cancer Center Cores to translate community-based EHS questions and concerns into specific scientific hypotheses that may be supported by CACHET through the Pilot Project Program (PPP). Furthermore, the IHSFC will facilitate projects that utilize the Human Health Exposure Analysis Resource (HHEAR), to further enhance CACHET opportunities to conduct expanded target and untargeted analyses of environmental relevance.

1.综合健康科学核心：摘要 综合健康科学设施核心（IHSFC）将提供基础设施和高度集中的跨 向CACHET成员提供纪律服务，包括获得队列和生物库;环境卫生 设计、实施和转化研究服务;人口活动的创新方法 使用传统和尖端技术（包括设备、传感器和可穿戴设备）进行暴露估计 和移动的应用程序技术;以及以地理空间建模挑战为重点的新型统计服务 混合物的评价。这一系列服务将提供工具，将基础研究转化为 支持疾病预防和减轻种族/民族环境健康差异的知识。 IHSFC将在伊利诺伊大学芝加哥分校（UIC）和芝加哥大学（UofC）担任领导职务， 并将利用这些机构现有的研究资源，确保核心支持用于 开发额外的关键资源来开展EHS工作。IHSFC用于满足以下需求的许多资源 我们两个研究所现有的CACHET研究人员的EHS转化研究需求， 通过利用这两个机构之间的合作， 机构特有的优势和不断增长的核心资源。IHSFC人员包括流行病学专家 研究设计、基于人群和临床的研究、标本采集和质量保证、暴露 支持上级暴露评估的技术和数据分析，以及与 现代环境卫生学。IHSFC人员将与环境部门的人员合作， 生物标志物设施核心（EBC），以解决涉及环境生物标志物的分子测定要求 人体生物材料中的暴露和环境特征。IHSFC还将提供 结果的解释，并促进结果传播到芝加哥社区和超越， 社区参与核心（CEC）。此外，IHSFC还将与CEC合作 作为相关机构CTSA和癌症中心核心，翻译基于社区的EHS问题， 通过试点项目计划，CACHET可能会支持特定的科学假设 （购买力平价）。此外，IHSFC将促进利用人类健康暴露分析资源的项目 （HHEAR），以进一步增加CACHET的机会，进行扩大的目标和非目标分析， 环境相关性。